ArticleInfection and immunity2000
Cellular and cytokine correlates of mucosal protection in murine model of oral candidiasis.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- An Integrated Platform for the Comprehensive Analysis of Host-Fungal Interactions in the Murine Tongue.Current protocols · 2026Article
- Moxidectin elevates Candida albicans ergosterol levels to synergize with polyenes against oral candidiasis.Applied microbiology and biotechnology · 2024Article
- Effects of Boric Acid Gel on VaginalFrontiers in immunology · 2022Article
- Article
- HIV Infection and Compromised Mucosal Immunity: Oral Manifestations and Systemic Inflammation.Frontiers in immunology · 2017Review
- A novel bioluminescence mouse model for monitoring oropharyngeal candidiasis in mice.Virulence · 2013Article
- IL-12 and related cytokines: function and regulatory implications in Candida albicans infection.Clinical & developmental immunology · 2011Review
- Macrophage-mediated responses to Candida albicans in mice expressing the human immunodeficiency virus type 1 transgene.Infection and immunity · 2009Article
- Animal models of mucosal Candida infection.FEMS microbiology letters · 2008Review
- Murine model of concurrent oral and vaginal Candida albicans colonization to study epithelial host-pathogen interactions.Microbes and infection · 2007Article
- Candidiasis--do we need to fight or to tolerate the Candida fungus?Folia microbiologica · 2007Review
- Reversal in fatigued athletes of a defect in interferon gamma secretion after administration of Lactobacillus acidophilus.British journal of sports medicine · 2006Article
- Enhanced clearance of Candida albicans from the oral cavities of mice following oral administration of Lactobacillus acidophilus.Clinical and experimental immunology · 2005Article
- Immunopathogenesis of oropharyngeal candidiasis in human immunodeficiency virus infection.Clinical microbiology reviews · 2004Review
- Primary role for CD4(+) T lymphocytes in recovery from oropharyngeal candidiasis.Infection and immunity · 2002Article
- Nitric oxide-enhanced resistance to oral candidiasis.Immunology · 2001Article
- T cells augment monocyte and neutrophil function in host resistance against oropharyngeal candidiasis.Infection and immunity · 2001Article
- Antigenic properties and processing requirements of 65-kilodalton mannoprotein, a major antigen target of anti-Candida human T-cell response, as disclosed by specific human T-cell clones.Infection and immunity · 2001Article
- AnJournal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Host protection against Candida albicans infection in a model of oral candidiasis involving infection-prone [DBA/2 (H-2(d))] and less infection-prone [BALB/c (H-2(d))] mouse strains was analyzed in terms of antibody and cellular responses, and in terms of cytokine patterns from regional lymph node cells. There was a selective expansion of gamma/delta(+) T-cell receptor cells, which correlated with the patterns of colonization in both mouse strains, with higher numbers of gamma/delta T cells detected in BALB/c mice. Antigen-induced T-cell proliferation was significantly higher in BALB/c mice than in DBA/2 mice. Higher levels of serum immunoglobulin G (IgG) and salivary IgA antibodies were detected in BALB/c mice than in DBA/2 mice, but only after the infection was cleared. The cervical lymph node cells from infected mice were assessed for interleukin-4 (IL-4), IL-12, and gamma interferon (IFN-gamma) mRNA gene expression by reverse transcription-PCR and protein production in the culture supernatants following restimulation in vitro. In BALB/c mice, an early increase in levels of IL-4, IFN-gamma, and IL-12 correlated with rapid elimination of C. albicans. In DBA/2 mice, where resolution of infection was delayed, IL-4 message expression was delayed and the IL-4 secretion level was lower. Neutralization of IL-4 by multiple injections of an anti-IL-4 monoclonal antibody in BALB/c mice resulted in increased carriage rate and delayed clearance of the yeasts. Collectively, the data suggest that the T-cell response to C. albicans in the regional lymph nodes which correlates best with rapid oral clearance of C. albicans is a balanced Th0 cytokine response involving early secretion of both IFN-gamma and IL-4.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.