ArticleAntimicrobial agents and chemotherapy2000
Efficacy of voriconazole in a guinea pig model of disseminated invasive aspergillosis.
Article in Antimicrobial agents and chemotherapy, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 79 citations in OpenAlex.
- Trial
- Review
- Efficacy of Voriconazole against Aspergillus fumigatus Infection Depends on Host Immune Function.Antimicrobial agents and chemotherapy · 2020Article
- Altered pulmonary capillary permeability in immunosuppressed guinea pigs infected withExperimental and therapeutic medicine · 2019Article
- Animal Models of Aspergillosis.Comparative medicine · 2018Review
- Modified release itraconazole amorphous solid dispersion to treat Aspergillus fumigatus: importance of the animal model selection.Drug development and industrial pharmacy · 2017Article
- Rodent Models of Invasive Aspergillosis due toFrontiers in microbiology · 2017Review
- Effect of cleistanthin A and B on adrenergic and cholinergic receptors.Pharmacognosy magazine · 2011Article
- Management of invasive aspergillosis in patients with COPD: rational use of voriconazole.International journal of chronic obstructive pulmonary disease · 2009Review
- Assessment of Aspergillus fumigatus burden in pulmonary tissue of guinea pigs by quantitative PCR, galactomannan enzyme immunoassay, and quantitative culture.Antimicrobial agents and chemotherapy · 2008Article
- Animal models: an important tool in mycology.Medical mycology · 2007Review
- Differential fungicidal activities of amphotericin B and voriconazole against Aspergillus species determined by microbroth methodology.Antimicrobial agents and chemotherapy · 2007Article
- New guinea pig model of Cryptococcal meningitis.Antimicrobial agents and chemotherapy · 2007Article
- Voriconazole in the management of nosocomial invasive fungal infections.Therapeutics and clinical risk management · 2006Article
- Sequential or combination antifungal therapy with voriconazole and liposomal amphotericin B in a Guinea pig model of invasive aspergillosis.Antimicrobial agents and chemotherapy · 2006Article
- Pharmacokinetic/pharmacodynamic profile of voriconazole.Clinical pharmacokinetics · 2006Review
- Comparative efficacies of conventional amphotericin b, liposomal amphotericin B (AmBisome), caspofungin, micafungin, and voriconazole alone and in combination against experimental murine central nervous system aspergillosis.Antimicrobial agents and chemotherapy · 2005Article
- The pathogenesis of fatal outcome in murine pulmonary aspergillosis depends on the neutrophil depletion strategy.Infection and immunity · 2005Article
- Determination of fungicidal activities against yeasts and molds: lessons learned from bactericidal testing and the need for standardization.Clinical microbiology reviews · 2004Review
- Activity of posaconazole combined with amphotericin B against Aspergillus flavus infection in mice: comparative studies in two laboratories.Antimicrobial agents and chemotherapy · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Voriconazole (VRC) was evaluated in an immunosuppressed-guinea pig model of invasive aspergillosis. VRC was more effective than amphotericin B or similar doses of itraconazole in the clearance of Aspergillus from tissues. VRC treatment regimens improved survival and significantly reduced tissue colony counts compared with those of controls.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.