ArticleAntimicrobial agents and chemotherapy2000
In vitro activities of the ketolides telithromycin (HMR 3647) and HMR 3004 compared to those of clarithromycin against slowly growing mycobacteria at pHs 6.8 and 7.4.
Article in Antimicrobial agents and chemotherapy, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 44 citations in OpenAlex.
- Steady-state plasma and intrapulmonary pharmacokinetics and pharmacodynamics of cethromycin.Antimicrobial agents and chemotherapy · 2004Trial
- Susceptibility of Mycobacterium avium sbsp paratuberculosis to monensin sodium or tilmicosin phosphate in vitro and resulting infectivity in a murine model.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2004Trial
- Review
- The Deconstructed Granuloma: A Complex High-Throughput Drug Screening Platform for the Discovery of Host-Directed Therapeutics Against Tuberculosis.Frontiers in cellular and infection microbiology · 2018Article
- Structural and functional characterization of Rv2966c protein reveals an RsmD-like methyltransferase from Mycobacterium tuberculosis and the role of its N-terminal domain in target recognition.The Journal of biological chemistry · 2011Article
- Susceptibility of Mycobacterium bovis BCG vaccine strains to antituberculous antibiotics.Antimicrobial agents and chemotherapy · 2009Article
- "In vitro" activities of antimycobacterial agents against Mycobacterium avium subsp. paratuberculosis linked to Crohn's disease and paratuberculosis.Annals of clinical microbiology and antimicrobials · 2006Article
- Intrinsic macrolide resistance of the Mycobacterium tuberculosis complex is inducible.Antimicrobial agents and chemotherapy · 2006Article
- In vitro and in vivo activities of macrolide derivatives against Mycobacterium tuberculosis.Antimicrobial agents and chemotherapy · 2005Article
- Growth, Congo Red agar colony morphotypes and antibiotic susceptibility testing of Mycobacterium avium subspecies paratuberculosis.Clinical medicine & research · 2004Article
- Molecular basis of intrinsic macrolide resistance in the Mycobacterium tuberculosis complex.Antimicrobial agents and chemotherapy · 2004Article
- Susceptibilities of Mycobacterium marinum to gatifloxacin, gemifloxacin, levofloxacin, linezolid, moxifloxacin, telithromycin, and quinupristin-dalfopristin (Synercid) compared to its susceptibilities to reference macrolides and quinolones.Antimicrobial agents and chemotherapy · 2002Article
- Activities of new macrolides and fluoroquinolones against Mycobacterium ulcerans infection in mice.Antimicrobial agents and chemotherapy · 2001Article
- Telithromycin.Drugs · 2001Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The in vitro activities of HMR 3647 (telithromycin) and HMR 3004, two novel semisynthetic ketolides, were investigated and compared with that of the reference macrolide drug, clarithromycin, against 34 strains of slowly growing mycobacteria at pHs 6.8 and 7.4, as determined radiometrically. The MICs at pH 7.4 were about 1 to 2 dilutions lower than those observed at pH 6.8. In terms of the highest to the lowest activity, the three antibiotics could be classified as follows: clarithromycin > HMR 3004 > HMR 3647. Among the species tested, Mycobacterium bovis BCG, M. ulcerans, M. avium, and M. paratuberculosis were moderately susceptible to HMR 3004 and HMR 3647 (MICs at pH 7.4, < or =5.0 and < or =20.0 microg/ml, respectively, versus < or =1.25 microg/ml for clarithromycin), whereas M. tuberculosis, M. africanum, M. bovis, and M. simiae were resistant (MICs, > or =10.0 and > or =40.0 microg/ml, respectively, at pH 7.4). Although not more active than clarithromycin in vitro, the high level of intracellular accumulation of the two ketolides inside phagocytes warrants further screening in experimental animal models.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.