ArticleThe Journal of physiology2000
Single channel properties of neuronal nicotinic ACh receptors in stratum radiatum interneurons of rat hippocampal slices.
Article in The Journal of physiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Heteromeric α7β2 Nicotinic Acetylcholine Receptors in the Brain.Trends in pharmacological sciences · 2016Review
- The effect of α7 nicotinic receptor activation on glutamatergic transmission in the hippocampus.Biochemical pharmacology · 2015Review
- Nicotinic ACh receptors as therapeutic targets in CNS disorders.Trends in pharmacological sciences · 2015Review
- Nicotinic ACh receptors in the hippocampal circuit; functional expression and role in synaptic plasticity.The Journal of physiology · 2014Review
- Molecules and circuits involved in nicotine addiction: The many faces of smoking.Neuropharmacology · 2014Review
- Direct and GABA-mediated indirect effects of nicotinic ACh receptor agonists on striatal neurones.The Journal of physiology · 2013Article
- Nicotine and pathological angiogenesis.Life sciences · 2012Review
- α7 nicotinic ACh receptors as a ligand-gated source of Ca(2+) ions: the search for a Ca(2+) optimum.Advances in experimental medicine and biology · 2012Review
- Fast synaptic transmission in the goldfish CNS mediated by multiple nicotinic receptors.The Journal of physiology · 2011Article
- Physiological concentrations of choline activate native alpha7-containing nicotinic acetylcholine receptors in the presence of PNU-120596 [1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)-urea].The Journal of pharmacology and experimental therapeutics · 2010Article
- Evaluation of Ca2+ permeability of nicotinic acetylcholine receptors in hypothalamic histaminergic neurons.Acta biochimica et biophysica Sinica · 2010Article
- Hippocampal interneurons co-express transcripts encoding the alpha7 nicotinic receptor subunit and the cannabinoid receptor 1.Neuroscience · 2008Article
- Functional somato-dendritic alpha7-containing nicotinic acetylcholine receptors in the rat basolateral amygdala complex.The Journal of physiology · 2006Article
- Neuronal nicotinic acetylcholine receptor expression and function on nonneuronal cells.The AAPS journal · 2006Review
- Ca2+ permeability of nicotinic acetylcholine receptors in rat hippocampal CA1 interneurones.The Journal of physiology · 2005Article
- Nicotinic acetylcholine receptors at glutamate synapses facilitate long-term depression or potentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Inhibition of neuronal nicotinic acetylcholine receptor channels expressed in Xenopus oocytes by beta-amyloid1-42 peptide.Journal of molecular neuroscience : MN · 2005Article
- Functional mapping and Ca2+ regulation of nicotinic acetylcholine receptor channels in rat hippocampal CA1 neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Rat nicotinic ACh receptor alpha7 and beta2 subunits co-assemble to form functional heteromeric nicotinic receptor channels.The Journal of physiology · 2002Article
- The single-channel properties of human acetylcholine alpha 7 receptors are altered by fusing alpha 7 to the green fluorescent protein.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
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2 authors at 1 institution in 1 country.
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Abstract
The single channel properties of neuronal nicotinic ACh receptors (nAChRs) were investigated in outside-out patches from CA1 stratum radiatum interneurons from thin slices of rat hippocampus. The application of ACh (10 microM to 1 mM) induced the opening of observable single channel currents with two distinct current levels, which corresponded to conductance levels of 38 +/- 3 and 62 +/- 2 pS. The 38 pS channel was observed in 10 % (n = 260) of patches, whereas the 62 pS channel was observed in 4 % of patches; these two channel types were most often observed independently. The alpha7-selective nAChR antagonist methyllycaconitine (MLA; 50 nM) reduced the open probability of the 38 pS channel by 73 %. In contrast, the 62 pS channel was unaffected by MLA, but instead was blocked by dihydro-beta-erythroidine (DHbetaE; 10 microM), a broad spectrum nAChR antagonist. These data suggest that rat hippocampal CA1 stratum radiatum interneurons in the slice possess at least two different types of functional nAChRs, an alpha7-containing subtype with a single channel conductance of 38 pS, and a non-alpha7 subtype with a single channel conductance of 62 pS.
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