ArticleThe Journal of physiology2000
A Kv3-like persistent, outwardly rectifying, Cs+-permeable, K+ current in rat subthalamic nucleus neurones.
Article in The Journal of physiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 65 citations in OpenAlex.
- Optimization of Pyrazole-Based Activators of Kv3.1.ACS medicinal chemistry letters · 2026Article
- Model-based design of subthalamic nucleus neurons using hybrid optimization.Journal of neurophysiology · 2026Article
- Cellular and synaptic specializations for sub-millisecond precision in the mammalian auditory brainstem.Frontiers in cellular neuroscience · 2025Review
- Cellular and Synaptic Dysfunctions in Parkinson's Disease: Stepping out of the Striatum.Cells · 2019Review
- Article
- Central neuromodulatory pathways regulating sympathetic activity in hypertension.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Review
- Intrinsic dynamics and synaptic inputs control the activity patterns of subthalamic nucleus neurons in health and in Parkinson's disease.Neuroscience · 2011Article
- Evidence against AMPA receptor-lacking glutamatergic synapses in the superficial dorsal horn of the rat spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- The role of Kv3-type potassium channels in cerebellar physiology and behavior.Cerebellum (London, England) · 2009Review
- Phase relationships support a role for coordinated activity in the indirect pathway in organizing slow oscillations in basal ganglia output after loss of dopamine.Neuroscience · 2007Article
- Silent plateau potentials, rhythmic bursts, and pacemaker firing: three patterns of activity that coexist in quadristable subthalamic neurons.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Spontaneous sleep modulates the firing pattern of parkinsonian subthalamic nucleus.Experimental brain research · 2006Article
- Functional interconnectivity between the globus pallidus and the subthalamic nucleus in the mouse brain slice.The Journal of physiology · 2005Article
- Globus pallidus neurons dynamically regulate the activity pattern of subthalamic nucleus neurons through the frequency-dependent activation of postsynaptic GABAA and GABAB receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Topiramate hyperpolarizes and modulates the slow poststimulus AHP of rat olfactory cortical neurones in vitro.British journal of pharmacology · 2004Article
- Apamin-sensitive small conductance calcium-activated potassium channels, through their selective coupling to voltage-gated calcium channels, are critical determinants of the precision, pace, and pattern of action potential generation in rat subthalamic nucleus neurons in vitro.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Developmental changes in membrane excitability and morphology of neurons in the nucleus angularis of the chicken.The Journal of physiology · 2003Article
- Active and passive membrane properties of rat sympathetic preganglionic neurones innervating the adrenal medulla.The Journal of physiology · 2002Article
- The switch of subthalamic neurons from an irregular to a bursting pattern does not solely depend on their GABAergic inputs in the anesthetic-free rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Pharmacological characterization of a non-inactivating outward current observed in mouse cerebellar Purkinje neurones.British journal of pharmacology · 2002Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A persistent outward K+ current (IPO), activated by depolarization from resting potential, has been identified and characterized in rat subthalamic nucleus (SThN) neurones using whole-cell voltage-clamp recording in brain slices. IPO both rapidly activated (tau = 8 ms at +5 mV) and deactivated (tau = 2 ms at -68 mV), while showing little inactivation. Tail current reversal potentials varied with extracellular K+ concentration in a Nernstian manner. Intracellular Cs+ did not alter either IPO amplitude or the voltage dependence of activation, but blocked transient (A-like) outward currents activated by depolarization. When extracellular K+ was replaced with Cs+, IPO tail current reversal potentials were dependent upon the extracellular Cs+ concentration, indicating an ability to conduct Cs+, as well as K+. IPO was blocked by Ba2+ (1 mM), 4-aminopyridine (1 mM) and tetraethylammonium (TEA; 20 mM), with an IC50 for TEA of 0.39 mM. The IPO conductance appeared maximal (38 nS) at around +27 mV, half-maximal at -13 mV, with the threshold for activation at around -38 mV. TEA (1 mM) blocked the action potential after-hyperpolarization and permitted accommodation of action potential firing at frequencies greater than around 200 Hz. We conclude that IPO, which shares many characteristics of currents attributable to Kv3.1 K+ channels, enables high-frequency spike trains in SThN neurones.
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