ArticleThe EMBO journal2000
Activation of the beta globin locus by transcription factors and chromatin modifiers.
Article in The EMBO journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 51 citations in OpenAlex.
- Single-cell transcriptomics reveals heterocellular γ-globin gene expression in Aγδβ-thalassemia.Blood advances · 2026Article
- Differential requirement of a distal regulatory region for pre-initiation complex formation at globin gene promoters.Nucleic acids research · 2009Article
- Subcellular transport of EKLF and switch-on of murine adult beta maj globin gene transcription.Molecular and cellular biology · 2007Article
- Alterations in expression and chromatin configuration of the alpha hemoglobin-stabilizing protein gene in erythroid Kruppel-like factor-deficient mice.Molecular and cellular biology · 2006Article
- The binding of the ubiquitous transcription factor Sp1 at the locus control region represses the expression of beta-like globin genes.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- The human beta-globin locus control region can silence as well as activate gene expression.Molecular and cellular biology · 2005Article
- Latency, chromatin remodeling, and reactivation of human cytomegalovirus in the dendritic cells of healthy carriers.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Multiple interactions between regulatory regions are required to stabilize an active chromatin hub.Genes & development · 2004Article
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- Distinct domains of erythroid Krüppel-like factor modulate chromatin remodeling and transactivation at the endogenous beta-globin gene promoter.Molecular and cellular biology · 2002Article
- Binding of Ikaros to the lambda5 promoter silences transcription through a mechanism that does not require heterochromatin formation.The EMBO journal · 2001Article
- Embryonic but not postnatal reexpression of hepatocyte nuclear factor 1alpha (HNF1alpha) can reactivate the silent phenylalanine hydroxylase gene in HNF1alpha-deficient hepatocytes.Molecular and cellular biology · 2001Article
- Site-specific acetylation by p300 or CREB binding protein regulates erythroid Krüppel-like factor transcriptional activity via its interaction with the SWI-SNF complex.Molecular and cellular biology · 2001Article
Corrections and comments
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Authors and funding
13 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Locus control regions (LCRs) alleviate chromatin-mediated transcriptional repression. Incomplete LCRs partially lose this property when integrated in transcriptionally restrictive genomic regions such as centromeres. This frequently results in position effect variegation (PEV), i.e. the suppression of expression in a proportion of the cells. Here we show that this PEV is influenced by the heterochromatic protein SUV39H1 and by the Polycomb group proteins M33 and BMI-1. A concentration variation of these proteins modulates the proportion of cells expressing human globins in a locus-dependent manner. Similarly, the transcription factors Sp1 or erythroid Krüppel-like factor (EKLF) also influence PEV, characterized by a change in the number of expressing cells and the chromatin structure of the locus. However, in contrast to results obtained in a euchromatic locus, EKLF influences the expression of the gamma- more than the beta-globin genes, suggesting that the relief of silencing is caused by the binding of EKLF to the LCR and that genes at an LCR proximal position are more likely to be in an open chromatin state than genes at a distal position.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.