ArticlePharmaceutical research2000
The solid state oxidation of methionine containing peptide: a preliminary study using time of flight secondary ion mass spectrometry.
Article in Pharmaceutical research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Imaging Mass Spectrometric Analysis of Neurotransmitters: A Review.Mass spectrometry (Tokyo, Japan) · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeA surface sensitive mass spectrometric technique: Time of Flight Secondary Ion Mass Spectrometry (ToF-SIMS) was introduced to study the solid state instability of a methionine containing peptide caused by the oxidation of the methionine residue.
methodsThe oxidation of a neuropeptide Methinonine-Enkephalin (ME) in air and under UV acceleration was studied by ToF-SIMS.
resultsThe apparent oxidation rate is defined by the peak ratio of oxidized molecular ion over unoxidized molecular ion. ME is oxidized at a faster rate to its sulfoxide derivative in the UV accelerated oxidation environment than in lab air. The calibration curve for evaluating the ionization probability ratio of the oxidized deprotonated molecular ion divided by the unoxidized deprotonated molecular ion was obtained. This could be used to extract the real oxidation rate of ME in the solid state.
conclusionsThe preliminary results showed that ToF-SIMS with simple sample handling, fast data acquisition, together with excellent surface sensitivity and detection limit could be an applicable and convenient tool to study peptide reactions in the solid state such as oxidation and deamidation process.
Indexed as
Identifiers
10990206What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.