ArticleGut2000
Perceptual responses in patients with inflammatory and functional bowel disease.
Article in Gut, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 186 citations in OpenAlex.
- Is altered central pain processing related to disease stage in chronic pancreatitis patients with pain? An exploratory study.PloS one · 2013Trial
- TRPM8 inhibits substance P release from primary sensory neurons via PKA/GSK-3beta to protect colonic epithelium in colitis.Cell death & disease · 2024Article
- Abdominal Pain in Inflammatory Bowel Disease: An Evidence-Based, Multidisciplinary Review.Crohn's & colitis 360 · 2023Article
- Transitional changes in gastrointestinal transit and rectal sensitivity from active to recovery of inflammation in a rodent model of colitis.Scientific reports · 2021Article
- Abdominal pain in quiescent inflammatory bowel disease.International journal of colorectal disease · 2021Article
- Altered brain structural connectivity in patients with longstanding gut inflammation is correlated with psychological symptoms and disease duration.NeuroImage. Clinical · 2021Article
- Visceral pain from colon and rectum: the mechanotransduction and biomechanics.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Galanin suppresses visceral afferent responses to noxious mechanical and inflammatory stimuli.Physiological reports · 2020Article
- Role of TRPV1 and TRPA1 Ion Channels in Inflammatory Bowel Diseases: Potential Therapeutic Targets?Pharmaceuticals (Basel, Switzerland) · 2019Review
- Neonatal immune challenge followed by adult immune challenge induces epigenetic-susceptibility to aggravated visceral hypersensitivity.Neurogastroenterology and motility · 2017Article
- Gastrointestinal symptom severity in irritable bowel syndrome, inflammatory bowel disease and the general population.Neurogastroenterology and motility · 2017Article
- Electroacupuncture Attenuates Visceral Hypersensitivity by Inhibiting JAK2/STAT3 Signaling Pathway in the Descending Pain Modulation System.Frontiers in neuroscience · 2017Article
- Pilot Study of Functional Magnetic Resonance Imaging Responses to Somatic Pain Stimuli in Youth With Functional and Inflammatory Gastrointestinal Disease.Journal of pediatric gastroenterology and nutrition · 2016Article
- IBS and IBD - separate entities or on a spectrum?Nature reviews. Gastroenterology & hepatology · 2016Review
- Diagnosis and management of functional symptoms in inflammatory bowel disease in remission.World journal of gastrointestinal pharmacology and therapeutics · 2016Review
- Visceral Hypersensitivity Is Provoked by 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Ileitis in Rats.Frontiers in pharmacology · 2016Article
- Condition-specific role of colonic inflammatory molecules in persistent functional colorectal hypersensitivity in the mouse.Neurogastroenterology and motility · 2014Article
- The multifaceted mast cell in inflammatory bowel disease.Inflammatory bowel diseases · 2014Review
- Anorectal complications and function in patients suffering from inflammatory bowel disease: a series of patients with long-term follow-up.International journal of colorectal disease · 2014Article
- Neuroanatomy of lower gastrointestinal pain disorders.World journal of gastroenterology · 2014Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsEnhanced visceral sensitivity following a transient inflammatory process in the gut has been postulated as an aetiological mechanism of irritable bowel syndrome (IBS). In this study we compared perceptual responses to rectosigmoid distension in patients with mild chronic inflammation of the rectum (ulcerative colitis (UC)) and patients without mucosal inflammation (IBS) to determine if chronic low grade mucosal inflammation may be a plausible explanation for rectosigmoid hypersensitivity reported in both IBS and UC patients.
methodsUC disease activity was quantified using activity index scores. Perception thresholds for discomfort during rectosigmoid distension were compared between 11 UC patients with quiescent or mild disease activity, 18 IBS patients, and 13 healthy controls.
resultsAlthough UC activity index scores negatively correlated with perceptual thresholds for discomfort (r=-0.76, p=0.016), UC patients had higher discomfort thresholds compared with IBS patients and controls before (p=0.02) and after (p<0.001) a noxious sigmoid conditioning stimulus.
conclusionsRectal perception was attenuated in UC but enhanced in IBS. In chronic mild inflammation, activation of antinociceptive mechanisms may prevent the development of visceral hyperalgesia. Low grade mucosal inflammation alone is unlikely to be responsible for symptoms in functional gastrointestinal disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.