ArticleAmerican journal of human genetics2000
Short tandem-repeat polymorphism/alu haplotype variation at the PLAT locus: implications for modern human origins.
Article in American journal of human genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 84 citations in OpenAlex.
- Infectious Disease Risk Across the Growing Human-Non Human Primate Interface: A Review of the Evidence.Frontiers in public health · 2019Review
- Modeling neutral evolution of Alu elements using a branching process.BMC genomics · 2010Article
- Replication cycle of chikungunya: a re-emerging arbovirus.Virology · 2009Review
- Modeling Informatively Missing Genotypes in Haplotype Analysis.Communications in statistics: theory and methods · 2009Article
- Genetic studies of African populations: an overview on disease susceptibility and response to vaccines and therapeutics.Human genetics · 2008Review
- Molecular evidence of founder effects of fatal familial insomnia through SNP haplotypes around the D178N mutation.Neurogenetics · 2008Article
- No evidence of a Neanderthal contribution to modern human diversity.Genome biology · 2008Review
- Distinct linkage disequilibrium (LD) runs of single nucleotide polymorphisms and microsatellite markers; implications for use of mixed marker haplotypes in LD-based mapping.Journal of Korean medical science · 2007Article
- Article
- The use of racial, ethnic, and ancestral categories in human genetics research.American journal of human genetics · 2005Review
- A comparison of linkage disequilibrium patterns and estimated population recombination rates across multiple populations.American journal of human genetics · 2005Article
- Evaluation of microsatellite markers in association studies: a search for an immune-related susceptibility gene in sarcoidosis.Immunogenetics · 2005Article
- Divergent patterns of linkage disequilibrium and haplotype structure across global populations at the interleukin-13 (IL13) locus.Genes and immunity · 2005Article
- DNA sequence variation of the human ABO-secretor locus ( FUT2) in New Guinean populations: possible early human migration from Africa.Human genetics · 2003Article
- Haplotypic relationship between SNP and microsatellite markers at the NOS2A locus in two populations.Genes and immunity · 2003Article
- Inconsistent designs of association studies: a missed opportunity.Molecular psychiatry · 2003Article
- Common 5' beta-globin RFLP haplotypes harbour a surprising level of ancestral sequence mosaicism.Human genetics · 2003Article
- Extensive linkage disequilibrium, a common 16.7-kilobase deletion, and evidence of balancing selection in the human protocadherin alpha cluster.American journal of human genetics · 2003Article
- Interrogating a high-density SNP map for signatures of natural selection.Genome research · 2002Article
- Evidence for balancing selection from nucleotide sequence analyses of human G6PD.American journal of human genetics · 2002Article
Corrections and comments
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Authors and funding
12 authors at 9 institutions in 7 countries.
Funding
Abstract
Two dinucleotide short tandem-repeat polymorphisms (STRPs) and a polymorphic Alu element spanning a 22-kb region of the PLAT locus on chromosome 8p12-q11.2 were typed in 1,287-1,420 individuals originating from 30 geographically diverse human populations, as well as in 29 great apes. These data were analyzed as haplotypes consisting of each of the dinucleotide repeats and the flanking Alu insertion/deletion polymorphism. The global pattern of STRP/Alu haplotype variation and linkage disequilibrium (LD) is informative for the reconstruction of human evolutionary history. Sub-Saharan African populations have high levels of haplotype diversity within and between populations, relative to non-Africans, and have highly divergent patterns of LD. Non-African populations have both a subset of the haplotype diversity present in Africa and a distinct pattern of LD. The pattern of haplotype variation and LD observed at the PLAT locus suggests a recent common ancestry of non-African populations, from a small population originating in eastern Africa. These data indicate that, throughout much of modern human history, sub-Saharan Africa has maintained both a large effective population size and a high level of population substructure. Additionally, Papua New Guinean and Micronesian populations have rare haplotypes observed otherwise only in African populations, suggesting ancient gene flow from Africa into Papua New Guinea, as well as gene flow between Melanesian and Micronesian populations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.