ReviewAmerican journal of human genetics2000
Mechanisms of genomic imprinting.
Review in American journal of human genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 109 citations in OpenAlex.
- A rapid review of genetic association studies of parent-of-origin effects and fetal growth.Molecular and cellular pediatrics · 2026Review
- Allelic expression patterns of imprinted and non-imprinted genes in cancer cell lines from multiple histologies.Clinical epigenetics · 2025Article
- Epigenetics and Asthma: A Systematic Review.Cureus · 2024Review
- Increased copy number of imprinted genes in the chromosomal region 20q11-q13.32 is associated with resistance to antitumor agents in cancer cell lines.Clinical epigenetics · 2022Article
- Muscle allele-specific expression QTLs may affect meat quality traits in Bos indicus.Scientific reports · 2021Article
- Venom Complexity in a Pitviper Produced by Facultative Parthenogenesis.Scientific reports · 2018Article
- The Effect of Vitrification on Expression and Histone Marks of Igf2 and Oct4 in Blastocysts Cultured from Two-Cell Mouse Embryos.Cell journal · 2018Article
- Carcinoma of the colon and rectum with deregulation of insulin-like growth factor 2 signaling: clinical and molecular implications.Journal of gastroenterology · 2016Article
- A powerful association test for qualitative traits incorporating imprinting effects using general pedigree data.Journal of human genetics · 2015Article
- Maternal telomere length inheritance in the king penguin.Heredity · 2015Article
- Parametric proportional hazards model for mapping genomic imprinting of survival traits.Journal of applied genetics · 2013Article
- Exploration of gene-environment interactions, maternal effects and parent of origin effects in the etiology of hypospadias.The Journal of urology · 2012Article
- Peromyscus as a Mammalian epigenetic model.Genetics research international · 2012Article
- Characterization of genomic imprinting effects and patterns with parametric accelerated failure time model.Molecular genetics and genomics : MGG · 2012Article
- A powerful approach for association analysis incorporating imprinting effects.Bioinformatics (Oxford, England) · 2011Article
- A statistical model for estimating maternal-zygotic interactions and parent-of-origin effects of QTLs for seed development.PloS one · 2008Article
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- Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
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- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Imprinted genes represent a curious defiance of normal Mendelian genetics. Mammals inherit two complete sets of chromosomes, one from the mother and one from the father, and most autosomal genes will be expressed from both the maternal and the paternal alleles. Imprinted genes, however, are expressed from only one chromosome, in a parent-of-origin-dependent manner. Because silent and active promoters are present in a single nucleus, the differences in activity cannot be explained by transcription-factor abundance. Thus, transcription of imprinted genes represents a clear situation in which epigenetic mechanisms restrict gene expression and, therefore, offers a model for understanding the role of DNA modifications and chromatin structure in maintaining appropriate patterns of expression. Furthermore, because of their parent-of-origin-restricted expression, phenotypes determined by imprinted genes are susceptible not only to genetic alterations in the genes but also to disruptions in the epigenetic programs controlling regulation. Imprinted genes are often associated with human diseases, including disorders affecting cell growth, development, and behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.