ArticleProceedings of the National Academy of Sciences of the United States of America2000
Shape anisotropy of a single random-walk polymer.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 83 citations in OpenAlex.
- Solution properties of spherical gold nanoparticles with grafted DNA chains from simulation and theory.Nanoscale advances · 2022Article
- Electroosmotic Flow Induced Lift Forces on Polymer Chains in Nanochannels.ACS polymers Au · 2022Article
- Computing 3D Chromatin Configurations from Contact Probability Maps by Inverse Brownian Dynamics.Biophysical journal · 2020Article
- Bridging the spatiotemporal scales of macromolecular transport in crowded biomimetic systems.Soft matter · 2019Article
- Crowding Induces Entropically-Driven Changes to DNA Dynamics That Depend on Crowder Structure and Ionic Conditions.Frontiers in physics · 2018Article
- Size distribution of ring polymers.Scientific reports · 2016Article
- Collapse of DNA under alternating electric fields.Physical review. E, Statistical, nonlinear, and soft matter physics · 2015Article
- Dimensional and temporal controls of three-dimensional cell migration by zyxin and binding partners.Nature communications · 2012Article
- Visualizing large RNA molecules in solution.RNA (New York, N.Y.) · 2012Article
- Fluctuation modes of nanoconfined DNA.Journal of applied physics · 2012Article
- Compression and self-entanglement of single DNA molecules under uniform electric field.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Density fluctuations dispersion relationship for a polymer confined to a nanotube.Applied physics letters · 2011Article
- The role of transcription factories-mediated interchromosomal contacts in the organization of nuclear architecture.Nucleic acids research · 2010Article
- A coarse-grained model for polyethylene oxide and polyethylene glycol: conformation and hydrodynamics.The journal of physical chemistry. B · 2009Article
- Entropic organization of interphase chromosomes.The Journal of cell biology · 2009Article
- Molecular dynamics studies of polyethylene oxide and polyethylene glycol: hydrodynamic radius and shape anisotropy.Biophysical journal · 2008Article
- Nuclear lamin A/C deficiency induces defects in cell mechanics, polarization, and migration.Biophysical journal · 2007Article
- Principal-components analysis of shape fluctuations of single DNA molecules.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Statistical coil model of the unfolded state: resolving the reconciliation problem.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Intracellular mechanics of migrating fibroblasts.Molecular biology of the cell · 2005Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Random walks have been used to describe a wide variety of systems ranging from cell colonies to polymers. Sixty-five years ago, Kuhn [Kuhn, W. (1934) Kolloid-Z. 68, 2-11] made the prediction, backed later by computer simulations, that the overall shape of a random-walk polymer is aspherical, yet no experimental work has directly tested Kuhn's general idea and subsequent computer simulations. By using fluorescence microscopy, we monitored the conformation of individual, long, random-walk polymers (fluorescently labeled DNA molecules) at equilibrium. We found that a polymer most frequently adopts highly extended, nonfractal structures with a strongly anisotropic shape. The ensemble-average ratio of the lengths of the long and short axes of the best-fit ellipse of the polymer was much larger than unity.
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