ArticleProceedings of the National Academy of Sciences of the United States of America2000
Fully competent dendritic cells as inducers of T cell anergy in autoimmunity.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 46 citations in OpenAlex.
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- Recombinant rabies virus with the glycoprotein fused with a DC-binding peptide is an efficacious rabies vaccine.Oncotarget · 2018Article
- Cell Migration Research Based on Organ-on-Chip-Related Approaches.Micromachines · 2017Review
- Dendritic Cell-based Immunotherapy for Rheumatoid Arthritis: from Bench to Bedside.Immune network · 2016Review
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- A novel cancer therapeutic using thrombospondin 1 in dendritic cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2014Article
- Distinct response of liver myeloid dendritic cells to endotoxin is mediated by IL-27.Journal of hepatology · 2009Article
- The cross-regulatory relationship between human dendritic and regulatory T cells and its role in type 1 diabetes mellitus.The review of diabetic studies : RDS · 2007Article
- The AIDS-like disease of CD4C/human immunodeficiency virus transgenic mice is associated with accumulation of immature CD11bHi dendritic cells.Journal of virology · 2003Article
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- Gene-modified dendritic cells for immunotherapy against cancer.Medical oncology (Northwood, London, England) · 2002Review
- Co-stimulatory and adhesion molecules of dendritic cells in rheumatoid arthritis.Journal of cellular and molecular medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Mature immunologically competent dendritic cells are the most efficient antigen-presenting cells that powerfully activate T cells and initiate and sustain immune responses. Indeed, dendritic cells are able to efficiently capture antigens, express high levels of costimulatory molecules, and produce the combination of cytokines required to create a powerful immune response. They are also considered to be important in initiating autoimmune disease by efficiently presenting autoantigens to self-reactive T cells that, in this case, will mount a pathogenic autoimmune reaction. Triggering T cells is not a simple on-off procedure, as T cell receptor responds to minor changes in ligand with gradations of T cell activation and effector functions. These "misfit" peptides have been called Altered Peptide Ligands, and have been shown to have important biological significance. Here, we show that fully capable dendritic cells may present, upon natural antigen processing, a self-epitope with Altered Peptide Ligands features that can unexpectedly induce anergy in a human autoreactive T cell clone. These results indicate that presentation of a self-epitope by immunologically competent dendritic cells does not always mean "danger" and show a mechanism involved in the fine balance between activation and tolerance induction in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.