ArticleProceedings of the National Academy of Sciences of the United States of America2000
N-terminal transcriptional activation domain of LZIP comprises two LxxLL motifs and the host cell factor-1 binding motif.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Article
- Beneficially Stressing the Peripheral Nervous System to Repair.International journal of molecular sciences · 2026Review
- Targeting CREBRF in Cancer: Mechanistic Insights and Future Directions.Biologics : targets & therapy · 2025Review
- Article
- Systematic Characterization of bZIP Transcription Factors Required for Development and Aflatoxin Generation by High-Throughput Gene Knockout inJournal of fungi (Basel, Switzerland) · 2022Article
- OsbZIP42 is a positive regulator of ABA signaling and confers drought tolerance to rice.Planta · 2019Article
- Elucidating post-translational regulation of mouse CREB3 in Neuro2a cells.Molecular and cellular biochemistry · 2018Article
- LUMAN/CREB3 Plays a Dual Role in Stress Responses as a Cofactor of the Glucocorticoid Receptor and a Regulator of Secretion.Frontiers in molecular neuroscience · 2018Article
- Small leucine zipper protein functions as a negative regulator of estrogen receptor α in breast cancer.PloS one · 2017Article
- A novel PPARγ2 modulator sLZIP controls the balance between adipogenesis and osteogenesis during mesenchymal stem cell differentiation.Cell death and differentiation · 2014Article
- The dynamics of HCF-1 modulation of herpes simplex virus chromatin during initiation of infection.Viruses · 2013Review
- The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression.Molecular and cellular biology · 2010Article
- HDAC3 selectively represses CREB3-mediated transcription and migration of metastatic breast cancer cells.Cellular and molecular life sciences : CMLS · 2010Article
- The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1.The Journal of biological chemistry · 2009Article
- A novel isoform of human LZIP negatively regulates the transactivation of the glucocorticoid receptor.Molecular endocrinology (Baltimore, Md.) · 2009Article
- A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein response.Molecular and cellular biology · 2008Article
- Conserved region I of human coactivator TAF4 binds to a short hydrophobic motif present in transcriptional regulators.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Host cell factor and an uncharacterized SANT domain protein are stable components of ATAC, a novel dAda2A/dGcn5-containing histone acetyltransferase complex in Drosophila.Molecular and cellular biology · 2006Article
- Activation of the Kaposi's sarcoma-associated herpesvirus major latency locus by the lytic switch protein RTA (ORF50).Journal of virology · 2005Article
- HCF-1 functions as a coactivator for the zinc finger protein Krox20.The Journal of biological chemistry · 2003Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Host Cell Factor-1 (HCF-1, C1) was first identified as a cellular target for the herpes simplex virus transcriptional activator VP16. Association between HCF and VP16 leads to the assembly of a multiprotein enhancer complex that stimulates viral immediate-early gene transcription. HCF-1 is expressed in all cells and is required for progression through G(1) phase of the cell cycle. In addition to VP16, HCF-1 associates with a cellular bZIP protein known as LZIP (or Luman). Both LZIP and VP16 contain a four-amino acid HCF-binding motif, recognized by the N-terminal beta-propeller domain of HCF-1. Herein, we show that the N-terminal 92 amino acids of LZIP contain a potent transcriptional activation domain composed of three elements: the HCF-binding motif and two LxxLL motifs. LxxLL motifs are found in a number of transcriptional coactivators and mediate protein-protein interactions, notably recognition of the nuclear hormone receptors. LZIP is an example of a sequence-specific DNA-binding protein that uses LxxLL motifs within its activation domain to stimulate transcription. The LxxLL motifs are not required for association with the HCF-1 beta-propeller and instead interact with other regions in HCF-1 or recruit additional cofactors.
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