ArticleGenome research2000
Identifying potential tumor markers and antigens by database mining and rapid expression screening.
Article in Genome research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 105 citations in OpenAlex.
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- Glycoprotein non-metastatic melanoma B expression after hepatic ischemia reperfusion and the effect of silibinin.Translational gastroenterology and hepatology · 2020Article
- ABC Transporters at the Blood-Brain Interfaces, Their Study Models, and Drug Delivery Implications in Gliomas.Pharmaceutics · 2019Review
- Identification of COL1A1 as an invasion‑related gene in malignant astrocytoma.International journal of oncology · 2018Article
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- Screening key candidate genes and pathways involved in insulinoma by microarray analysis.Medicine · 2018Observational
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- The data obtained during the analysis of clinical blood samples for children acute lymphoblastic leukemia patients with severe side-effects.Data in brief · 2017Article
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- Intrathecal siRNA against GPNMB attenuates nociception in a rat model of neuropathic pain.Journal of molecular neuroscience : MN · 2015Article
- Bioinformatics for cancer immunotherapy target discovery.Cancer immunology, immunotherapy : CII · 2014Review
- Targeted induction of apoptosis in glioblastoma multiforme cells by an MRP3-specific TRAIL fusion protein in vitro.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Expression and immunolocalization of Gpnmb, a glioma-associated glycoprotein, in normal and inflamed central nervous systems of adult rats.Brain and behavior · 2012Article
- Toxin-based targeted therapy for malignant brain tumors.Clinical & developmental immunology · 2012Review
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- Affinity-matured anti-glycoprotein NMB recombinant immunotoxins targeting malignant gliomas and melanomas.International journal of cancer · 2011Article
- Errors in CGAP xProfiler and cDNA DGED: the importance of library parsing and gene selection algorithms.BMC bioinformatics · 2011Article
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- Identification of HTA as a novel-specific marker for human hepatocellular carcinoma.Journal of cancer research and clinical oncology · 2010Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genes expressed specifically in malignant tissue may have potential as therapeutic targets but have been difficult to locate for most cancers. The information hidden within certain public databases can reveal RNA transcripts specifically expressed in transformed tissue. To be useful, database information must be verified and a more complete pattern of tissue expression must be demonstrated. We tested database mining plus rapid screening by fluorescent-PCR expression comparison (F-PEC) as an approach to locate candidate brain tumor antigens. Cancer Genome Anatomy Project (CGAP) data was mined for genes highly expressed in glioblastoma multiforme. From 13 mined genes, seven showed potential as possible tumor markers or antigens as determined by further expression profiling. Now that large-scale expression information is readily available for many of the commonly occurring cancers, other candidate tumor markers or antigens could be located and evaluated with this approach.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.