Trial reportThe Journal of allergy and clinical immunology2000
Intranasal fluticasone propionate does not prevent acute otitis media during viral upper respiratory infection in children.
Trial report in The Journal of allergy and clinical immunology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 54 citations in OpenAlex.
- Trial
- Effect of Ganduqing on common cold: A protocol for systematic review and meta-analysis based on existing evidence.Medicine · 2020Article
- Outcome risk factors during respiratory infections in a paediatric ward in Antananarivo, Madagascar 2010-2012.PloS one · 2013Article
- Viral etiology of common cold in children, Finland.Emerging infectious diseases · 2009Article
- Editorial commentary: Respiratory viral infections in developing countries: common, severe, and unrecognized.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2008Article
- Microbiology of acute otitis media in children with tympanostomy tubes: prevalences of bacteria and viruses.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2006Article
- Viral upper respiratory tract infections in young children with emphasis on acute otitis media.International journal of pediatric otorhinolaryngology · 2006Review
- Bacterial coinfections in children with viral wheezing.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2006Article
- Respiratory picornaviruses and respiratory syncytial virus as causative agents of acute expiratory wheezing in children.Emerging infectious diseases · 2004Article
- Prevention of otitis media caused by viral upper respiratory tract infection: vaccines, antivirals, and other approaches.Current allergy and asthma reports · 2003Review
- Viral otitis media.Current allergy and asthma reports · 2003Review
- The common cold.Lancet (London, England) · 2003Review
- Rhinovirus-induced wheezing in infancy--the first sign of childhood asthma?The Journal of allergy and clinical immunology · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAcute otitis media (AOM) is the most common complication of a viral upper respiratory infection (URI) in children. The virus-induced host inflammatory response in the nasopharynx plays a key role in the pathogenesis of AOM. Suppression of this inflammatory process might prevent the development of AOM as a complication.
objectiveWe sought to assess the effect of intranasally administered fluticasone propionate on prevention of AOM during a viral respiratory infection.
methodsA total of 210 children (mean age, 2.1 years; range, 0.7-3.9 years) with normal middle ear status and URI of 48 hours' duration or less were randomly allocated to receive either fluticasone (100 microg twice daily) or placebo for 7 days. The specific viral cause of the infection was determined from nasopharyngeal aspirates obtained at the first visit. The children were re-examined at the end of the 7-day medication period.
resultsIn the fluticasone group AOM developed in 40 (38.1%) of 105 children compared with 29 (28.2%) of 103 children receiving placebo (P =.13). The viral cause of the respiratory infection was determined in 167 (86.1%) of 194 children from whom a nasopharyngeal aspirate was obtained. In children with rhinovirus infection, AOM developed significantly more often in the fluticasone group (45.7%) than in the placebo group (14.7%, P =.005).
conclusionIntranasally administered fluticasone does not prevent the development of AOM during URI but may increase the incidence of AOM during rhinovirus infection.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.