ArticleNucleic acids research2000
Role of FXR and FTF in bile acid-mediated suppression of cholesterol 7alpha-hydroxylase transcription.
Article in Nucleic acids research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 83 citations in OpenAlex.
- Endoplasmic reticulum stress at the forefront of fatty liver diseases and cancer.Pharmacological reviews · 2025Review
- Differential Modulation of Nuclear Receptor LRH-1 through Targeting Buried and Surface Regions of the Binding Pocket.Journal of medicinal chemistry · 2022Article
- Identification of transcription factors and single nucleotide polymorphisms of Lrh1 and its homologous genes in Lrh1-knockout pancreas of mice.BMC medical genetics · 2014Article
- Vertical sleeve gastrectomy reduces hepatic steatosis while increasing serum bile acids in a weight-loss-independent manner.Obesity (Silver Spring, Md.) · 2014Article
- Phospholipid--driven gene regulation.FEBS letters · 2013Review
- FXR signaling in the enterohepatic system.Molecular and cellular endocrinology · 2013Review
- Nuclear receptors HNF4α and LRH-1 cooperate in regulating Cyp7a1 in vivo.The Journal of biological chemistry · 2012Article
- Nuclear receptor control of enterohepatic circulation.Comprehensive Physiology · 2012Review
- Insulin-dependent suppression of cholesterol 7α-hydroxylase is a possible link between glucose and cholesterol metabolisms.Experimental & molecular medicine · 2011Article
- Hepatic free cholesterol accumulates in obese, diabetic mice and causes nonalcoholic steatohepatitis.Gastroenterology · 2011Article
- Emerging actions of the nuclear receptor LRH-1 in the gut.Biochimica et biophysica acta · 2011Review
- Mechanisms for increased expression of cholesterol 7alpha-hydroxylase (Cyp7a1) in lactating rats.Hepatology (Baltimore, Md.) · 2010Article
- Hepatic bile acid metabolism in the neonatal hamster: expansion of the bile acid pool parallels increased Cyp7a1 expression levels.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action.The Journal of biological chemistry · 2009Article
- 25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway.American journal of physiology. Endocrinology and metabolism · 2008Article
- Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis.Molecular endocrinology (Baltimore, Md.) · 2008Article
- Liver receptor homolog 1 transcriptionally regulates human bile salt export pump expression.Journal of lipid research · 2008Article
- Activation of bile acid biosynthesis by the p38 mitogen-activated protein kinase (MAPK): hepatocyte nuclear factor-4alpha phosphorylation by the p38 MAPK is required for cholesterol 7alpha-hydroxylase expression.The Journal of biological chemistry · 2007Article
- Role of an mSin3A-Swi/Snf chromatin remodeling complex in the feedback repression of bile acid biosynthesis by SHP.Molecular and cellular biology · 2004Article
- Cholestasis.Gut · 2003Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Bile acid biosynthesis is subjected to feedback regulation whereby bile acids down-regulate their own synthesis. The major point of this regulation is at the level of cholesterol 7alpha-hydroxylase (7alpha-hydroxylase), which controls bile acid output from the classic pathway. This regulation is at the level of transcription of the gene. Two bile acid response elements have been localized within the 5'-flanking region of the rat gene and these elements overlap three nuclear receptor binding sites for hepatocyte nuclear factor (HNF-4), liver X receptor (LXR) and alpha(1)-fetoprotein transcription factor (FTF). Recently it has been shown that bile acids are physiological ligands for the farnesyl X receptor (FXR), which suggested that FXR could function by binding to one of the three nuclear receptor sites to mediate regulation of 7alpha-hydroxylase transcription by bile acids. In this study we show that FXR is indeed a crucial factor for bile acid-mediated regulation, but that it functions without binding to DNA. Furthermore, we also demonstrate that neither the LXR nor the HNF-4 sites are involved in bile acid-mediated regulation of 7alpha-hydroxylase transcription. Most importantly, we show that the FTF site is essential for regulation of 7alpha-hydroxylase by bile acids, similar to what we have recently demonstrated for another gene of the bile acid biosynthetic pathway, the sterol 12alpha-hydroxylase gene. These studies demonstrate the crucial role of FTF in the expression and regulation of a critical gene in the bile acid biosynthetic pathways.
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