ArticleNucleic acids research2000
Transcriptional activation by the PHD finger is inhibited through an adjacent leucine zipper that binds 14-3-3 proteins.
Article in Nucleic acids research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- Comprehensive analysis of HB-PHD transcription factors associated with drought and salt stresses in wheat.BMC genomics · 2026Article
- WUSCHEL-dependent chromatin regulation in maize inflorescence development at single-cell resolution.Genome biology · 2025Article
- Cytological and Molecular Mechanism of Low Pollen Grain Viability in a Germplasm Line of Double Lotus.Plants (Basel, Switzerland) · 2023Article
- Genome-Wide Identification and In Silico Analysis of ZF-HD Transcription Factor Genes inGenes · 2022Article
- MDM2 induces EMT via the B‑Raf signaling pathway through 14‑3‑3.Oncology reports · 2021Article
- Genome-wide identification of ZF-HD gene family in Triticum aestivum: Molecular evolution mechanism and function analysis.PloS one · 2021Article
- Functional characterization ofPeerJ · 2021Article
- Zinc Finger-Homeodomain Transcriptional Factors (ZHDs) in Upland Cotton (Frontiers in genetics · 2018Article
- PHF7, a novel male gene influences female fecundity and population growth in Nilaparvata lugens Stål (Hemiptera: Delphacidae).Scientific reports · 2017Article
- Anther-preferential expressing gene PMR is essential for the mitosis of pollen development in rice.Plant cell reports · 2017Article
- Genome-wide analysis and expression patterns of ZF-HD transcription factors under different developmental tissues and abiotic stresses in Chinese cabbage.Molecular genetics and genomics : MGG · 2016Article
- Prunus transcription factors: breeding perspectives.Frontiers in plant science · 2015Review
- Genome-wide identification, evolution and expression analysis of the grape (Vitis vinifera L.) zinc finger-homeodomain gene family.International journal of molecular sciences · 2014Article
- The yeast two-hybrid and related methods as powerful tools to study plant cell signalling.Plant molecular biology · 2013Review
- Unexplored potentials of epigenetic mechanisms of plants and animals-theoretical considerations.Genetics & epigenetics · 2013Review
- PERSISTENT TAPETAL CELL1 encodes a PHD-finger protein that is required for tapetal cell death and pollen development in rice.Plant physiology · 2011Article
- Proteome profiling of early seed development in Cunninghamia lanceolata (Lamb.) Hook.Journal of experimental botany · 2010Article
- CXXC finger protein 1 restricts the Setd1A histone H3K4 methyltransferase complex to euchromatin.The FEBS journal · 2010Article
- Soybean GmPHD-type transcription regulators improve stress tolerance in transgenic Arabidopsis plants.PloS one · 2009Article
- CXXC finger protein 1 contains redundant functional domains that support embryonic stem cell cytosine methylation, histone methylation, and differentiation.Molecular and cellular biology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The PHD finger, a Cys(4)-His-Cys(3) zinc finger, is found in many regulatory proteins from plants or animals which are frequently associated with chromatin-mediated transcriptional regulation. We show here that the PHD finger activates transcription in yeast, plant and animal cells. In plant homeodomain transcription factors the PHD finger is combined with an upstream leucine zipper. Both domains together form a highly conserved 180 amino acid region called the ZIP/PHDf motif and transcriptional activity of the PHD finger is masked when embedded in this motif. Our results indicate that the ZIP/PHDf domain is a potential regulatory domain of PHDf-HD proteins. The leucine zipper upstream of the PHD finger interacts with 14-3-3GF14 mu from Arabidopsis thaliana and 14-3-3GF14-12 from maize via a leucine zipper conserved in helix 4 of various 14-3-3 proteins from plants and animals. PHD-type plant homeodomain proteins consequently may represent potential targets of 14-3-3 signalling.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.