ArticleMolecular and cellular biology2000
c-Src signaling induced by the adapters Sin and Cas is mediated by Rap1 GTPase.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- Deciphering the Role of BCAR3 in Cancer Progression: Gene Regulation, Signal Transduction, and Therapeutic Implications.Cancers · 2024Review
- Article
- Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability.Immunology and cell biology · 2016Article
- XB130: A novel adaptor protein in cancer signal transduction.Biomedical reports · 2016Article
- Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members.Gene · 2015Review
- Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer's disease.Oncoscience · 2014Article
- Identification of targets of c-Src tyrosine kinase by chemical complementation and phosphoproteomics.Molecular & cellular proteomics : MCP · 2012Article
- Cellular settings mediating Src Substrate switching between focal adhesion kinase tyrosine 861 and CUB-domain-containing protein 1 (CDCP1) tyrosine 734.The Journal of biological chemistry · 2011Article
- NEDD9 and BCAR1 negatively regulate E-cadherin membrane localization, and promote E-cadherin degradation.PloS one · 2011Article
- BCAR3 regulates Src/p130 Cas association, Src kinase activity, and breast cancer adhesion signaling.The Journal of biological chemistry · 2010Article
- The adapter molecule Sin regulates T-cell-receptor-mediated signal transduction by modulating signaling substrate availability.Molecular and cellular biology · 2004Article
- G-protein-coupled receptor-mediated activation of rap GTPases: characterization of a novel Galphai regulated pathway.Oncogene · 2004Article
- Adaptor protein Crk is required for ephrin-B1-induced membrane ruffling and focal complex assembly of human aortic endothelial cells.Molecular biology of the cell · 2002Article
- Focal adhesions require catalytic activity of Src family kinases to mediate integrin-matrix adhesion.Molecular and cellular biology · 2002Article
- Article
- Review
- Functions of the adapter protein Cas: signal convergence and the determination of cellular responses.Oncogene · 2001Review
- Regulation of Cbl phosphorylation by the Abl tyrosine kinase and the Nck SH2/SH3 adaptor.Oncogene · 2001Article
- Cyclic AMP-mediated inhibition of cell growth requires the small G protein Rap1.Molecular and cellular biology · 2001Article
- G protein coupled receptor signaling through the Src and Stat3 pathway: role in proliferation and transformation.Oncogene · 2001Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oncogenic Src proteins have been extensively studied to gain insight into the signaling mechanisms of Src. To better understand signaling through wild-type Src, we used an approach that involves activation of Src signaling through the binding of physiologic ligands to the Src SH3 domain. To this end, we used full-length and truncated versions of the multiadapter molecules Cas and Sin to activate c-Src, and we examined the intracellular pathways that mediate Src signaling under these conditions. We show that although all proteins bind to and are phosphorylated by c-Src, quantitative differences exist in the ability of the different ligands to activate c-Src signaling. In addition, we show that Sin- and Cas-induced Src signaling, as assayed by transcriptional activation, is exclusively mediated through a pathway that involves the adapter Crk and the GTP-binding protein Rap1. These data are in contrast to previous observations showing Ras to mediate signaling downstream of transforming Src alleles. In our system, we found that signaling through the oncogenic SrcY527 mutant is indeed mediated by Ras. In addition, we found that Rap1 also mediates oncogenic Src signaling. Our results show for the first time that Rap1 mediates c-Src kinase signaling and reveal mechanistic differences in the signaling properties of wild-type and transforming Src proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.