ArticleMolecular and cellular biology2000
dCtBP-dependent and -independent repression activities of the Drosophila Knirps protein.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
- Epigenetic inheritance and gene expression regulation in early Drosophila embryos.EMBO reports · 2024Review
- CBP and Gcn5 drive zygotic genome activation independently of their catalytic activity.Science advances · 2023Article
- Shadow enhancers modulate distinct transcriptional parameters that differentially effect downstream patterning events.Development (Cambridge, England) · 2022Article
- A Looping-Based Model for Quenching Repression.PLoS computational biology · 2017Article
- Transcriptional Timers Regulating Mitosis in Early Drosophila Embryos.Cell reports · 2016Article
- Brinker possesses multiple mechanisms for repression because its primary co-repressor, Groucho, may be unavailable in some cell types.Development (Cambridge, England) · 2013Article
- A dissection of the teashirt and tiptop genes reveals a novel mechanism for regulating transcription factor activity.Developmental biology · 2011Article
- The oligomeric state of CtBP determines its role as a transcriptional co-activator and co-repressor of Wingless targets.The EMBO journal · 2011Article
- The gap gene network.Cellular and molecular life sciences : CMLS · 2011Review
- Thermodynamics-based models of transcriptional regulation by enhancers: the roles of synergistic activation, cooperative binding and short-range repression.PLoS computational biology · 2010Article
- Transcriptional repression: conserved and evolved features.Current biology : CB · 2010Review
- CtBP levels control intergenic transcripts, PHO/YY1 DNA binding, and PcG recruitment to DNA.Journal of cellular biochemistry · 2010Article
- Groucho corepressor functions as a cofactor for the Knirps short-range transcriptional repressor.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Organization of developmental enhancers in the Drosophila embryo.Nucleic acids research · 2009Article
- Multiple modular promoter elements drive graded brinker expression in response to the Dpp morphogen gradient.Development (Cambridge, England) · 2008Article
- Structurally related Arabidopsis ANGUSTIFOLIA is functionally distinct from the transcriptional corepressor CtBP.Development genes and evolution · 2007Article
- Functional interaction between the Drosophila knirps short range transcriptional repressor and RPD3 histone deacetylase.The Journal of biological chemistry · 2005Article
- cis-regulatory logic of short-range transcriptional repression in Drosophila melanogaster.Molecular and cellular biology · 2005Article
- CtBP contributes quantitatively to Knirps repression activity in an NAD binding-dependent manner.Molecular and cellular biology · 2004Article
- Functional similarity of Knirps CtBP-dependent and CtBP-independent transcriptional repressor activities.Nucleic acids research · 2003Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Transcriptional repressor proteins play essential roles in controlling the correct temporal and spatial patterns of gene expression in Drosophila melanogaster embryogenesis. Repressors such as Knirps, Krüppel, and Snail mediate short-range repression and interact with the dCtBP corepressor. The mechanism by which short-range repressors block transcription is not well understood; therefore, we have undertaken a detailed structure-function analysis of the Knirps protein. To provide a physiological setting for measurement of repression, the activities of endogenous or chimeric Knirps repressor proteins were assayed on integrated reporter genes in transgenic embryos. Two distinct repression functions were identified in Knirps. One repression activity depends on dCtBP binding, and this function maps to a C-terminal region of Knirps that contains a dCtBP binding motif. In addition, an N-terminal region was identified that represses in a CtBP mutant background and does not bind to the dCtBP protein in vitro. Although the dCtBP protein is important for Knirps activity on some genes, one endogenous target of the Knirps protein, the even-skipped stripe 3 enhancer, is not derepressed in a CtBP mutant. These results indicate that Knirps can utilize two different pathways to mediate transcriptional repression and suggest that the phenomenon of short-range repression may be a combination of independent activities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.