ArticleMolecular biology of the cell2000
Association of prenylated proteins with the plasma membrane and the inner nuclear membrane is mediated by the same membrane-targeting motifs.
Article in Molecular biology of the cell, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- S-farnesylation is essential for antiviral activity of the long ZAP isoform against RNA viruses with diverse replication strategies.PLoS pathogens · 2021Article
- Review
- Supramolecular Structures of theCells · 2019Article
- Neurotransmitter-mediated activity spatially controls neuronal migration in the zebrafish cerebellum.PLoS biology · 2018Article
- Evolutionary changes in lamin expression in the vertebrate lineage.Nucleus (Austin, Tex.) · 2017Article
- Involvement of RARRES3 in the regulation of Wnt proteins acylation and signaling activities in human breast cancer cells.Cell death and differentiation · 2015Article
- The induction of a nucleoplasmic reticulum by prelamin A accumulation requires CTP:phosphocholine cytidylyltransferase-α.Journal of cell science · 2011Article
- Targeting of Nbp1 to the inner nuclear membrane is essential for spindle pole body duplication.The EMBO journal · 2011Article
- Mechanobiology and the microcirculation: cellular, nuclear and fluid mechanics.Microcirculation (New York, N.Y. : 1994) · 2010Review
- C-terminal anchoring of mid1p to membranes stabilizes cytokinetic ring position in early mitosis in fission yeast.Molecular and cellular biology · 2004Article
- ARHI is a Ras-related small G-protein with a novel N-terminal extension that inhibits growth of ovarian and breast cancers.Oncogene · 2003Article
- Intranuclear membranes induced by lipidated proteins are derived from the nuclear envelope.Nucleus (Austin, Tex.)Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Targeting of nuclear lamins to the inner nuclear envelope membrane requires a nuclear localization signal and CaaX motif-dependent posttranslational modifications, including isoprenylation and carboxyl methylation. These modifications, although necessary for membrane targeting, are not sufficient to mediate stable association with membranes. We show that two variants of lamin B3 (i.e., B3a and B3b) exist in Xenopus oocytes. They are encoded by two alternatively spliced, developmentally regulated mRNAs. The two lamin variants differ greatly in their membrane association in meiotically matured eggs. The presence of an extra cysteine residue (as a potential palmitoylation site) and a basic cluster in conjunction with the CaaX motif function as secondary targeting signals responsible for the stable membrane association of lamin B3b in Xenopus eggs. Moreover, transfection experiments with Green Fluorescent Protein lamin tail chimeras and with a Green Fluorescent Protein N-Ras chimera show that these secondary motifs are sufficient to target proteins to the inner nuclear membrane and/or the plasma membrane. Implications for the intracellular trafficking of doubly lipidated proteins are discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.