ArticleMolecular biology of the cell2000
Neuronal cell shape and neurite initiation are regulated by the Ndr kinase SAX-1, a member of the Orb6/COT-1/warts serine/threonine kinase family.
Article in Molecular biology of the cell, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 101 citations in OpenAlex.
- NDR kinase SAX-1 controls dendrite branch-specific elimination during neuronal remodeling in C. elegans.The EMBO journal · 2026Article
- Temperature-specific regulation of the NDR kinase Orb6 by the MAPK Sty1 to promote heat stress resilience.Journal of cell science · 2026Article
- Dopey-dependent regulation of extracellular vesicles maintains neuronal morphology.Current biology : CB · 2024Article
- Dopey-dependent regulation of extracellular vesicles maintains neuronal morphology.bioRxiv : the preprint server for biology · 2024Article
- The contribution of an X chromosome QTL to non-Mendelian inheritance and unequal chromosomal segregation in Auanema freiburgense.Genetics · 2024Article
- The NDR family of kinases: essential regulators of aging.Frontiers in molecular neuroscience · 2024Review
- The Role of Mammalian STK38 in DNA Damage Response and Targeting for Radio-Sensitization.Cancers · 2023Review
- The cell cortex-localized protein CHDP-1 is required for dendritic development and transport in C. elegans neurons.PLoS genetics · 2022Article
- Furry is required for cell movements during gastrulation and functionally interacts with NDR1.Scientific reports · 2021Article
- Ndr kinases regulate retinal interneuron proliferation and homeostasis.Scientific reports · 2018Article
- Activation of RHO-1 in cholinergic motor neurons competes with dopamine signalling to control locomotion.PloS one · 2018Article
- Ndr2 Kinase Controls Neurite Outgrowth and Dendritic Branching Through αFrontiers in molecular neuroscience · 2018Article
- Infrared laser-induced gene expression for tracking development and function of single C. elegans embryonic neurons.Nature communications · 2017Article
- Article
- Pioneer Axon Navigation Is Controlled by AEX-3, a Guanine Nucleotide Exchange Factor for RAB-3 in Caenorhabditis elegans.Genetics · 2016Article
- Novel DLK-independent neuronal regeneration in Caenorhabditis elegans shares links with activity-dependent ectopic outgrowth.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Phosphorylation-dependent inhibition of Cdc42 GEF Gef1 by 14-3-3 protein Rad24 spatially regulates Cdc42 GTPase activity and oscillatory dynamics during cell morphogenesis.Molecular biology of the cell · 2015Article
- MST kinases in development and disease.The Journal of cell biology · 2015Review
- MST3 kinase phosphorylates TAO1/2 to enable Myosin Va function in promoting spine synapse development.Neuron · 2014Article
- Rassf5 and Ndr kinases regulate neuronal polarity through Par3 phosphorylation in a novel pathway.Journal of cell science · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Caenorhabditis elegans sax-1 gene regulates several aspects of neuronal cell shape. sax-1 mutants have expanded cell bodies and ectopic neurites in many classes of neurons, suggesting that SAX-1 functions to restrict cell and neurite growth. The ectopic neurites in sensory neurons of sax-1 mutants resemble the defects caused by decreased sensory activity. However, the activity-dependent pathway, mediated in part by the UNC-43 calcium/calmodulin-dependent kinase II, functions in parallel with SAX-1 to suppress neurite initiation. sax-1 encodes a serine/threonine kinase in the Ndr family that is related to the Orb6 (Schizosaccharomyces pombe), Warts/Lats (Drosophila), and COT-1 (Neurospora) kinases that function in cell shape regulation. These kinases have similarity to Rho kinases but lack consensus Rho-binding domains. Dominant negative mutations in the C. elegans RhoA GTPase cause neuronal cell shape defects similar to those of sax-1 mutants, and genetic interactions between rhoA and sax-1 suggest shared functions. These results suggest that SAX-1/Ndr kinases are endogenous inhibitors of neurite initiation and cell spreading.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.