ArticleJournal of virology2000
Sindbis-group alphavirus replication in periosteum and endosteum of long bones in adult mice.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- The life cycle of the alphaviruses: From an antiviral perspective.Antiviral research · 2023Pooled it
- The pathogenicity and virulence of Sindbis virus.Virulence · 2026Review
- Structural and Functional Hallmarks of Sindbis Virus Proteins: From Virion Architecture to Pathogenesis.International journal of molecular sciences · 2025Review
- Current and future treatments for sickle cell disease: From hematopoietic stem cell transplantation to in vivo gene therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Review
- Infectivity and pathogenesis characterization of getah virus (GETV) strain via different inoculation routes in mice.Heliyon · 2024Article
- Unraveling the complex interplay: immunopathology and immune evasion strategies of alphaviruses with emphasis on neurological implications.Frontiers in cellular and infection microbiology · 2024Review
- Chronic Joint Pain 3 Years after Chikungunya Virus Infection Largely Characterized by Relapsing-remitting Symptoms.The Journal of rheumatology · 2020Article
- Mayaro: an emerging viral threat?Emerging microbes & infections · 2018Review
- The growth of arthralgic Ross River virus is restricted in human monocytic cells.Virus research · 2016Article
- Article
- Dissecting the Role of E2 Protein Domains in Alphavirus Pathogenicity.Journal of virology · 2015Article
- Protective and Pathogenic Responses to Chikungunya Virus Infection.Current tropical medicine reports · 2015Article
- Osteoblasts from osteoarthritis patients show enhanced susceptibility to Ross River virus infection associated with delayed type I interferon responses.Virology journal · 2014Article
- Closing the gap between viral and noninfectious arthritis.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Arthritogenic alphaviral infection perturbs osteoblast function and triggers pathologic bone loss.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Molecular mechanisms involved in the pathogenesis of alphavirus-induced arthritis.BioMed research international · 2013Review
- Interferon response factors 3 and 7 protect against Chikungunya virus hemorrhagic fever and shock.Journal of virology · 2012Article
- Arthritogenic alphaviruses--an overview.Nature reviews. Rheumatology · 2012Review
- A determinant of Sindbis virus neurovirulence enables efficient disruption of Jak/STAT signaling.Journal of virology · 2010Article
- Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages.The Journal of clinical investigation · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Several alphaviruses, including the Sindbis-group viruses, Ross River virus, O'nyong-nyong virus, and Chikungunya virus, are associated with outbreaks of acute and persistent arthralgia and arthritis in humans. Mechanisms underlying alphavirus-induced arthralgia and arthritis are not clearly understood, though direct viral replication within or around the affected joints is thought to contribute to disease. S.A.AR86 is a Sindbis-group alphavirus closely related to the arthralgia-associated Ockelbo and Girdwood S.A viruses. Following inoculation with S.A.AR86 derived from a molecular clone, infectious virus was isolated from bone and joint tissue 1 to 6 days postinfection. Studies using either in situ hybridization or S.A.AR86-derived double promoter viruses and replicons expressing green fluorescent protein localized sites of viral replication to the periosteum, tendons, and endosteum within the epiphyses of the long bones adjacent to articular joints. These results demonstrate that alphaviruses associated with arthralgia in humans replicate within bone-associated connective tissue adjacent to articular joints in an adult mouse model.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.