ArticleJournal of virology2000
Putative immunodominant human immunodeficiency virus-specific CD8(+) T-cell responses cannot be predicted by major histocompatibility complex class I haplotype.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00027482 (Studies of Specific Immune Responses in HIV-Infected and HIV-Uninfected Volunteers), which is not on this map. Cited by 55 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Studies of Specific Immune Responses in HIV-Infected and HIV-Uninfected Volunteers
Who cites it
55 citing papers in PubMed, 150 citations in OpenAlex.
- Structured antiretroviral treatment interruptions in chronically HIV-1-infected subjects.Proceedings of the National Academy of Sciences of the United States of America · 2001Trial
- Incomplete T-cell tolerance and epitope-specific responses to the NR1 subunit in NMDA receptor antibody-associated encephalitis.Brain communications · 2026Article
- An Overview of Peptides and Peptide Pools for Antigen-Specific Stimulation in T-Cell Assays.Methods in molecular biology (Clifton, N.J.) · 2024Review
- Article
- CMV-Specific T-cell Responses at Older Ages: Broad Responses With a Large Central Memory Component May Be Key to Long-term Survival.The Journal of infectious diseases · 2017Article
- Multiparameter Flow Cytometric Assays to Quantify Effector and Regulatory T-Cell Function in Multiple Sclerosis.Journal of multiple sclerosis · 2015Article
- HCV-specific interleukin-21+CD4+ T cells responses associated with viral control through the modulation of HCV-specific CD8+ T cells function in chronic hepatitis C patients.Molecules and cells · 2013Article
- Emerging microfluidic tools for functional cellular immunophenotyping: a new potential paradigm for immune status characterization.Frontiers in oncology · 2013Article
- Superior control of HIV-1 replication by CD8+ T cells targeting conserved epitopes: implications for HIV vaccine design.PloS one · 2013Article
- Role of T-cell epitope-based vaccine in prophylactic and therapeutic applications.Future virology · 2012Article
- Conditional CD8+ T cell escape during acute simian immunodeficiency virus infection.Journal of virology · 2012Article
- Article
- Identification of CD8+ T cell epitopes in the West Nile virus polyprotein by reverse-immunology using NetCTL.PloS one · 2010Article
- Article
- Functional properties and epitope characteristics of T-cells recognizing natural HIV-1 variants.Vaccine · 2009Article
- Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance.Nature immunology · 2009Article
- Clonotype analysis of cytomegalovirus-specific cytotoxic T lymphocytes.Journal of the American Society of Nephrology : JASN · 2009Article
- Optimizing peptide matrices for identifying T-cell antigens.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2008Article
- A novel approach to evaluate the immunogenicity of viral antigens of clinical importance in HLA transgenic murine models.Immunology letters · 2008Article
- Antiretroviral drug therapy alters the profile of human immunodeficiency virus type 1-specific T-cell responses and shifts the immunodominant cytotoxic T-lymphocyte response from Gag to Pol.Journal of virology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Recent studies of human immunodeficiency virus (HIV)-specific CD8(+) T cells have focused on responses to single, usually HLA-A2-restricted epitopes as surrogate measures of the overall response to HIV. However, the assumption that a response to one epitope is representative of the total response is unconfirmed. Here we assess epitope immunodominance and HIV-specific CD8(+) T-cell response complexity using cytokine flow cytometry to examine CD8(+) T-cell responses in 11 HLA-A2(+) HIV(+) individuals. Initial studies demonstrated that only 4 of 11 patients recognized the putative immunodominant HLA-A2-restricted p17 epitope SLYNTVATL, suggesting that the remaining subjects might lack significant HIV-specific CD8(+) T-cell responses. However, five of six SLYNTVATL nonresponders recognized other HIV epitopes, and two of four SLYNTVATL responders had greater responses to HIV peptides restricted by other class I alleles. In several individuals, no HLA-A2-restricted epitopes were recognized, but CD8(+) T-cell responses were detected to epitopes restricted by other HLA class I alleles. These data indicate that an individual's overall CD8(+) T-cell response to HIV is not adequately represented by the response to a single epitope and that individual major histocompatibility complex class I alleles do not predict an immunodominant response restricted by that allele. Accurate quantification of total HIV-specific CD8(+) T-cell responses will require assessment of the response to all possible epitopes.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.