ArticleBone marrow transplantation2000
Complications after bone marrow transplantation are manifestations of systemic inflammatory response syndrome.
Article in Bone marrow transplantation, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- The clinical value of biomarkers in respiratory complications in hematopoietic SCT.Bone marrow transplantation · 2017Trial
- Early-onset acute kidney injury is a poor prognostic sign for allogeneic SCT recipients.Bone marrow transplantation · 2015Trial
- Selenium supplementation in patients undergoing hematopoietic stem cell transplantation: effects on pro-inflammatory cytokines levels.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2014Trial
- Organ dysfunction following stem cell transplantation: relationship to plasma cytokine concentrations.Bone marrow transplantation · 2001Trial
- Oral eicosapentaenoic acid for complications of bone marrow transplantation.Bone marrow transplantation · 2001Trial
- CRP patterns and clinical associations in febrile patients undergoing autologous bone marrow transplant: experience from the sole transplant center in the West Bank, Palestine.Annals of hematology · 2026Article
- Novel insights into diagnosis and management of hyperreactivity: a narrative review.Journal of thoracic disease · 2025Review
- Mindfulness vs. sleep education during autologous hematopoietic cell transplantation for multiple myeloma: Feasibility of a randomized controlled pilot study.Contemporary clinical trials communications · 2025Article
- Article
- Upregulation of Insulin-like Growth Factor-I in Response to Chemotherapy in Children with Acute Lymphoblastic Leukemia.International journal of molecular sciences · 2024Article
- Neurological involvement in hematopoietic stem cell transplantation-associated thrombotic microangiopathy.Annals of hematology · 2024Review
- Transplant-associated thrombotic microangiopathy: theoretical considerations and a practical approach to an unrefined diagnosis.Bone marrow transplantation · 2021Review
- Glucagon-Like Peptide-1 Is Associated With Systemic Inflammation in Pediatric Patients Treated With Hematopoietic Stem Cell Transplantation.Frontiers in immunology · 2021Article
- Allogeneic reactivity-mediated endothelial cell complications after HSCT: a plea for consensual definitions.Blood advances · 2019Review
- Innovative strategies minimize engraftment syndrome in multiple myeloma patients with novel induction therapy following autologous hematopoietic stem cell transplantation.Bone marrow transplantation · 2018Article
- Coordinated responses of natural anticoagulants to allogeneic stem cell transplantation and acute GVHD - A longitudinal study.PloS one · 2017Article
- Adaptive Immune Response Impairs the Efficacy of Autologous Transplantation of Engineered Stem Cells in Dystrophic Dogs.Molecular therapy : the journal of the American Society of Gene Therapy · 2016Article
- A new paradigm: Diagnosis and management of HSCT-associated thrombotic microangiopathy as multi-system endothelial injury.Blood reviews · 2015Review
- Engraftment syndrome: double-edged sword of hematopoietic cell transplants.Bone marrow transplantation · 2015Review
- An autopsy case that manifested no convincing histological changes of severe renal failure after hematopoietic stem cell transplantation.CEN case reports · 2014Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone marrow transplantation has been established as a useful treatment for various hematological disorders and is now performed widely, but the mortality rate is still high due to various complications. A clear therapeutic policy for such complications has not yet been established because of their complex nature. We investigated whether the major complications occurring after bone marrow transplantation could be classified as aspects of the systemic inflammatory response syndrome. Subjects were 10 patients who developed severe complications after bone marrow transplantation (graft-versus-host disease, thrombotic microangiopathy, respiratory disorders, and cytomegalovirus interstitial pneumonitis) and 16 patients without complications. Their symptoms, serum cytokines, and factors related to vascular endothelial damage were compared before and after transplantation. Whereas all 10 patients who developed complications had fever in the aplastic phase after transplantation, 15 of the 16 patients without complications remained afebrile (P < 0.001, t-test). When compared with the patients who did not develop complications, the patients with complications also showed significantly higher cytokine levels during the recovery phase after transplantation (P < 0.0001, t-test). Thus, the patients with complications developed fever in the aplastic phase and showed an increase of cytokines during the recovery phase, which triggered the occurrence of vascular endothelial damage shown by factors such as the thrombomodulin and plasminogen activator inhibitor type 1. This sequence of events corresponds with that occurring during systemic inflammatory response syndrome, so many of the complications of bone marrow transplantation can be considered as manifestations of this syndrome.
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Registered trials
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