ReviewCurrent hypertension reports2000
Aldosterone and vascular damage.
Review in Current hypertension reports, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 109 citations in OpenAlex.
- Spironolactone reduces brachial pulse wave velocity and PIIINP levels in hypertensive diabetic patients.British journal of clinical pharmacology · 2005Trial
- Relationship between plasma aldosterone levels and arterial stiffness parameters in hypertensive patients with subclinical vascular damage.International journal of cardiology. Cardiovascular risk and prevention · 2022Article
- Analysis of the miRNA expression from the adipose tissue surrounding the adrenal neoplasia.Frontiers in cardiovascular medicine · 2022Article
- Coincidence of Large Adrenal Cyst and Prominent Hyporeninemic Hyperaldosteronism.Case reports in endocrinology · 2021Article
- Cardiomyopathies and Adrenal Diseases.International journal of molecular sciences · 2020Review
- Effects of hypoestrogenism and/or hyperaldosteronism on myocardial remodeling in female mice.Physiological reports · 2018Article
- Relationship of Genetic Polymorphisms of Aldosterone Synthase Gene Cytochrome P450 11B2 and Mineralocorticoid Receptors with Coronary Artery Disease in Taiwan.International journal of medical sciences · 2016Article
- Aldosterone dysregulation with aging predicts renal vascular function and cardiovascular risk.Hypertension (Dallas, Tex. : 1979) · 2014Article
- An emerging concept of vascular salt sensitivity.F1000 biology reports · 2012Article
- Impact of medical therapy on atheroma volume measured by different cardiovascular imaging modalities.Cardiology research and practice · 2010Article
- Intensified inhibition of renin-angiotensin system: a way to improve renal protection?Current hypertension reports · 2009Article
- Contrasting effects of eplerenone and spironolactone on adrenal cell steroidogenesis.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2009Article
- Aldosterone induces endothelial dysfunction in resistance arteries from normotensive and hypertensive rats by increasing thromboxane A2 and prostacyclin.British journal of pharmacology · 2008Article
- Intensified inhibition of renin-angiotensin system: a way to improve renal protection?Current hypertension reports · 2007Review
- The role of aldosterone in resistant hypertension: implications for pathogenesis and therapy.Current hypertension reports · 2007Review
- Aldosterone and the vasculature: mechanisms mediating resistant hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2007Review
- Cardiorenal disease: a clinical intersection.International urology and nephrology · 2005Review
- Endothelial cell swelling by aldosterone.The Journal of membrane biology · 2003Article
- Aldosterone as a determinant of cardiovascular and renal dysfunction.Journal of the Royal Society of Medicine · 2001Review
- Blockade of the renin-angiotensin system in African Americans with hypertension and cardiovascular disease.Journal of clinical hypertension (Greenwich, Conn.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the aldosterone escape mechanism is well known, aldosterone has often been neglected in the pathophysiologic consequences of the activated renin-angiotensin-aldosterone system in arterial hypertension and chronic heart failure. There is now evidence for vascular synthesis of aldosterone aside from its secretion by the adrenal cortex. Moreover, aldosterone is involved in vascular smooth muscle cell hypertrophy and hyperplasia, as well as in vascular matrix impairment and endothelial dysfunction. The mechanisms of action of aldosterone may be either delayed (genomic) or rapid (nongenomic). Deleterious effects of aldosterone leading to vascular target-organ damage include (besides salt and water retention) decreased arterial and venous compliance, increased peripheral vascular resistance, and impaired autonomic vascular control due to baroreflex dysfunction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.