ReviewCurrent hypertension reports2000
Strategy for uncovering complex determinants of hypertension using animal models.
Review in Current hypertension reports, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 8 citations in OpenAlex.
- Vitamin B6: a molecule for human health?Molecules (Basel, Switzerland) · 2010Review
- Manipulating the mouse genome: approaches and applications.Journal of nuclear cardiology : official publication of the American Society of Nuclear CardiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Hypertension is a complex, multifactorial disorder resulting from the interaction of multiple genetic and environmental factors. While rodent models of hypertension have proved useful for identifying chromosomal regions containing blood pressure quantitative trait loci (QTLs), the gene(s) responsible for strain-differences in blood pressure remain to be identified. A strategy for identifying the genetic factors underlying blood pressure in animal models is presented, grouped according to the following themes: 1) choice of hypertension model, 2) identification of chromosomal regions containing QTLs, 3) confirming the presence of QTLs and delimiting the chromosomal region containing them, 4) developing a physical map of the QTL-containing region of the chromosome, 5) identification of strong candidate gene(s), and 6) requirements for proving that a gene is responsible, in part, for blood pressure differences.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.