ReviewCurrent hypertension reports2000
Renal dopamine and sodium homeostasis.
Review in Current hypertension reports, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00685919 (Kidney Dopamine Effects on Urinary Sodium Excretion in Postural Tachycardia Syndrome), which is not on this map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Kidney Dopamine Effects on Urinary Sodium Excretion in Postural Tachycardia Syndrome
Who cites it
19 citing papers in PubMed, 51 citations in OpenAlex.
- The dopamine receptor agonist rotigotine attenuated indomethacin-induced enteropathy in the small intestinal mucosa of mice.Molecular biology reports · 2025Article
- The Intricacies of Renal Phosphate Reabsorption-An Overview.International journal of molecular sciences · 2024Review
- Dopamine reduces cell surface NaAmerican journal of physiology. Renal physiology · 2017Article
- A case control association study of COMT gene polymorphism (I/D) with type 2 diabetes and its related factors in Pakistani Punjabi population.Journal of diabetes and metabolic disorders · 2015Article
- Effects of dehydration and blockade of angiotensin II AT1 receptor on stress hormones and anti-oxidants in the one-humped camel.BMC veterinary research · 2013Article
- Chronic regulation of the renal Na(+)/H(+) exchanger NHE3 by dopamine: translational and posttranslational mechanisms.American journal of physiology. Renal physiology · 2013Article
- NHERF-1 and the regulation of renal phosphate reabsoption: a tale of three hormones.American journal of physiology. Renal physiology · 2012Article
- Altered functioning of both renal dopamine D1 and angiotensin II type 1 receptors causes hypertension in old rats.Hypertension (Dallas, Tex. : 1979) · 2012Article
- Urodilatin increases renal dopamine uptake: intracellular network involved.Journal of physiology and biochemistry · 2011Article
- Oxidative stress alters renal D1 and AT1 receptor functions and increases blood pressure in old rats.American journal of physiology. Renal physiology · 2011Article
- Dopamine receptor subtypes in the native human heart.Heart and vessels · 2010Article
- Effects of long-term ouabain treatment on blood pressure, sodium excretion, and renal dopamine D(1) receptor levels in rats.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2010Article
- Exercise activates redox-sensitive transcription factors and restores renal D1 receptor function in old rats.American journal of physiology. Renal physiology · 2009Article
- Inhibition of natriuretic factors increases blood pressure in rats.American journal of physiology. Renal physiology · 2009Article
- Renal proximal tubules from old Fischer 344 rats grow into epithelial cells in cultures and exhibit increased oxidative stress and reduced D1 receptor function.American journal of physiology. Cell physiology · 2008Article
- Dopamine receptors and hypertension.Current hypertension reports · 2008Review
- Association of dopaminergic pathway gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes.BMC genetics · 2008Article
- Dopamine D2-like receptor-mediated opening of K+ channels in opossum kidney cells.British journal of pharmacology · 2003Article
- Dopamine receptor-coupling defect in hypertension.Current hypertension reports · 2002Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During the past decade, it has become evident that dopamine plays an important role in the regulation of fluid and electrolyte balance and blood pressure. Dopamine exerts its actions through two families of dopamine receptors, designated D1-like and D2-like, which are identical in the brain and in peripheral tissues. The two D1-like receptors--D1 and D5 receptors--expressed in mammals are linked to stimulation of adenylyl cyclase. The three D2-like receptors--D2, D3, and D4,--are linked to inhibition of adenylyl cyclase. Dopamine affects fluid and electrolyte balance by regulation of renal excretion of electrolytes and water through actions on renal hemodynamics and tubular epithelial transport and by modulation of the secretion and/or action of vasopressin, renin, aldosterone, catecholamines, and endothelin B receptors (ETB) receptors. It also affects fluid and sodium intake by way of "appetite" centers in the brain and alterations of gastrointestinal tract transport. The production of dopamine in neural and non-neural tissues and the presence of receptors in these tissues suggest that dopamine can act in an autocrine or paracrine fashion. This renal autocrine-paracrine function, which becomes most evident during extracellular fluid volume expansion, is lost in essential hypertension and in some animal models of genetic hypertension. This deficit may be caused by abnormalities in renal dopamine production and polymorphisms or abnormal post-translational modification and regulation of dopamine receptor subtypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.