ReviewCurrent hypertension reports
Angiotensinogen variants and human hypertension.
Review in Current hypertension reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 56 citations in OpenAlex.
- Blood Levels of Angiotensinogen and Hypertension in the Multi-Ethnic Study of Atherosclerosis (MESA).Journal of the American College of Cardiology · 2023Article
- Polymorphism AGT2 (rs4762) is involved in the development of dermatologic events: Proof-of-concept in hepatocellular carcinoma patients treated with sorafenib.World journal of hepatology · 2022Article
- The Angiotensin-(1-12)/Chymase axis as an alternate component of the tissue renin angiotensin system.Molecular and cellular endocrinology · 2021Review
- Cardiovascular Research in France.Circulation research · 2018Article
- Update of the human and mouse SERPIN gene superfamily.Human genomics · 2013Review
- Carotid artery intima-media thickness and the renin-angiotensin system.Hospital practice (1995) · 2013Review
- The "his and hers" of the renin-angiotensin system.Current hypertension reports · 2013Review
- Transgenic mice overexpressing Renin exhibit glucose intolerance and diet-genotype interactions.Frontiers in endocrinology · 2012Article
- The genetics of white matter lesions.CNS neuroscience & therapeutics · 2011Review
- RAAS and adrenergic genes in heart failure: Function, predisposition and survival implications.World journal of cardiology · 2010Article
- Genetics of the human renin angiotensin system.Journal of molecular medicine (Berlin, Germany) · 2008Review
- Association of angiotensinogen haplotypes with angiotensinogen levels but not with blood pressure or coronary artery disease: the Ludwigshafen Risk and Cardiovascular Health Study.Journal of molecular medicine (Berlin, Germany) · 2005Article
- Multilocus effects of the renin-angiotensin-aldosterone system genes on blood pressure response to a thiazide diuretic.The pharmacogenomics journal · 2004Article
- Lack of association between the G protein beta3 subunit gene and essential hypertension in Chinese: a case-control and a family-based study.Journal of molecular medicine (Berlin, Germany) · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The research on molecular genetics of human hypertension aims to identify the loci involved in the regulation of blood pressure, detect gene variants within the identified loci, associate them with intermediate phenotypes, and ultimately estimate their quantitative effects on blood pressure level and their interaction with main environmental factors. So far, the angiotensinogen (AGT) gene is one of the few candidate genes that has been investigated using these multiple statistical, clinical, and biochemical strategies. A highly polymorphic dinucleotide GT repeat (80% heterozygosity) has been used in several linkage studies. Other diallelic polymorphisms, located in the 5' regulatory region of the gene in intronic and exonic sequences, have been described, which were then used in association studies in different clinical settings. Positive associations between the M235T and the G-6A polymorphisms and plasma angiotensinogen levels indicates a pathway by which the AGT locus could be involved in essential hypertension.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.