Evidence map›Paper›PMID 10981039›Full record

ReviewCurrent hypertension reports

Use of animal models to search for candidate genes associated with essential hypertension.

M Knoblauch, K Lindpaintner

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current hypertension reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 3 countries.

M KnoblauchMax Delbrueck Center of Molecular Medicine, Berlin, Germany.
K Lindpaintner
Harvard University · USMax Delbrück Center · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of inbred genetically hypertensive animal models enables the dissection of the underlying complex genetic traits into its individual components, and thus the elucidation and characterization of causative genes and gene variants. In addition, genetically hypertensive animal models will also be useful for the investigation of genetic characteristics that influence the effectiveness of antihypertensive therapy with specific pharmacologic agents. This report will discuss three different strategies that have recently been used for the identification of candidate gene loci or candidate genes for hypertension. The possibility to transfer of genetic data derived in animal models to human hypertension will also be considered.

Indexed as

Disease Models, AnimalModels, GeneticAnimalsChromosome MappingCrosses, GeneticGene Expression ProfilingGenetic MarkersHumansHypertensionRatsRats, Inbred StrainsGenetic Markers

Identifiers

PMID10981039
OpenAlexW2007306186

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.