ReviewCurrent gastroenterology reports1999
Neuromuscular control of esophageal peristalsis.
Review in Current gastroenterology reports, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 57 citations in OpenAlex.
- Randomized clinical trial: effect of the 5-HT4 receptor agonist revexepride on reflux parameters in patients with persistent reflux symptoms despite PPI treatment.Neurogastroenterology and motility · 2015Trial
- Influence of intraluminal acidification on esophageal secondary peristalsis in humans.Digestive diseases and sciences · 2013Trial
- Results of the laparoscopic Heller-Dor procedure for pediatric esophageal achalasia.Surgical endoscopy · 2003Trial
- Modeling based insights into mechanical dysfunction in esophageal motility disorders.PLoS computational biology · 2025Article
- Influence of Menthol Infusion on Esophageal Peristalsis in Patients With Ineffective Esophageal Motility.Journal of neurogastroenterology and motility · 2024Article
- Relevance of ineffective esophageal motility to striated esophageal muscle contraction: Studies with high-resolution manometry.The Kaohsiung journal of medical sciences · 2024Article
- Expression of inducible nitric oxide synthase, nitrotyrosine, eosinophilic peroxidase, eotaxin-3, and galectin-3 in patients with gastroesophageal reflux disease, eosinophilic esophagitis, and in healthy controls: a semiquantitative image analysis of 3,3'-diaminobenzidine-stained esophageal biopsies.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2024Article
- Esophageal Dysmotility in Multiple System Atrophy: A Retrospective Cross-Sectional Study.Journal of clinical medicine · 2024Article
- Investigation of vagal sensory neurons in mice using optical vagal stimulation and tracheal neuroanatomy.iScience · 2024Article
- Advances in the Treatment of Dysphagia in Neurological Disorders: A Review of Current Evidence and Future Considerations.Neuropsychiatric disease and treatment · 2022Review
- A Comparative Assessment of the Diagnosis of Swallowing Impairment and Gastroesophageal Reflux in Canines and Humans.Frontiers in veterinary science · 2022Review
- Management of Ineffective Esophageal Hypomotility.Frontiers in pharmacology · 2021Review
- Tissue engineering of the gastroesophageal junction.Journal of tissue engineering and regenerative medicine · 2020Review
- Influence of GABA-B Agonist Baclofen on Capsaicin-Induced Excitation of Secondary Peristalsis in Humans.Clinical and translational gastroenterology · 2017Article
- Review
- Effects of anti-hypertensive drugs on esophageal body contraction.World journal of gastroenterology · 2010Article
- Contractile properties of esophageal striated muscle: comparison with cardiac and skeletal muscles in rats.Journal of biomedicine & biotechnology · 2010Article
- Real-time dynamics of nitric oxide shifts within the esophageal wall.Surgical endoscopy · 2009Article
- Role of intrinsic nitrergic neurones on vagally mediated striated muscle contractions in the hamster oesophagus.The Journal of physiology · 2003Article
- Advances in esophageal organoids: from construction to applications.Journal of tissue engineeringReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The esophagus is a muscular conduit connecting the pharynx and the stomach. Its function is controlled by an intrinsic nervous system and by input from the central nervous system through the vagus nerve. Peristalsis in its striated muscle is directed by sequential vagal excitation arising in the brain stem, whereas peristalsis in its smooth muscle involves complex interactions among the central and peripheral neural systems and the smooth muscle elements of the esophagus. The peripheral neuronal elements responsible for producing esophageal off-response, relaxation of the lower esophageal sphincter, and hyperpolarization of the circular esophageal muscle cells reside in the myenteric plexus of the esophagus. For many years these nerves were considered nonadrenergic and noncholinergic because the inhibitory neurotransmitter released on their activation was unknown. We now know that nitric oxide or a related compound is that inhibitory neurotransmitter. The primary excitatory neurotransmitter controlling esophageal motor function is acetylcholine. Some disorders of esophageal motor function, including diffuse esophageal spasm and achalasia, may result from defects in or an imbalance between these excitatory and inhibitory neuromuscular systems.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.