ReviewCurrent cardiology reports2000
Failing energetics in failing hearts.
Review in Current cardiology reports, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 97 citations in OpenAlex.
- Creatine nanoliposome reverts the HPA-induced damage in complex II-III activity of the rats' cerebral cortex.Molecular biology reports · 2019Article
- The value of serum metabolomics analysis in predicting the response to cardiac resynchronization therapy.Journal of geriatric cardiology : JGC · 2019Article
- Recent Advances in Cardiac Magnetic Resonance Imaging.Korean circulation journal · 2019Review
- Neuroprotective Effect of Creatine and Pyruvate on Enzyme Activities of Phosphoryl Transfer Network and Oxidative Stress Alterations Caused by Leucine Administration in Wistar Rats.Neurotoxicity research · 2017Article
- Evaluation of Oxidative Stress Parameters and Energy Metabolism in Cerebral Cortex of Rats Subjected to Sarcosine Administration.Molecular neurobiology · 2017Article
- Cardiac resynchronization therapy induces adaptive metabolic transitions in the metabolomic profile of heart failure.Journal of cardiac failure · 2015Article
- Assessment of changes in energy metabolism parameters provoked by carbon tetrachloride in Wistar rats and the protective effect of white grape juice.Toxicology reports · 2015Article
- Decline of Phosphotransfer and Substrate Supply Metabolic Circuits Hinders ATP Cycling in Aging Myocardium.PloS one · 2015Article
- Creatine and pyruvate prevent the alterations caused by tyrosine on parameters of oxidative stress and enzyme activities of phosphoryltransfer network in cerebral cortex of Wistar rats.Molecular neurobiology · 2015Article
- Co-administration of creatine plus pyruvate prevents the effects of phenylalanine administration to female rats during pregnancy and lactation on enzymes activity of energy metabolism in cerebral cortex and hippocampus of the offspring.Neurochemical research · 2014Article
- A technique for in vivo mapping of myocardial creatine kinase metabolism.Nature medicine · 2014Article
- ATPase may play a critical role in disturbance of energy metabolism in congestive heart failure rats.International journal of clinical and experimental medicine · 2014Article
- Cardiac metabolism in hypertrophy and heart failure: implications for therapy.Heart failure reviews · 2013Review
- Technology platform development for targeted plasma metabolites in human heart failure.Clinical proteomics · 2013Article
- 18O-assisted dynamic metabolomics for individualized diagnostics and treatment of human diseases.Croatian medical journal · 2012Review
- Effect of histidine administration to female rats during pregnancy and lactation on enzymes activity of phosphoryltransfer network in cerebral cortex and hippocampus of the offspring.Metabolic brain disease · 2012Article
- Tyrosine impairs enzymes of energy metabolism in cerebral cortex of rats.Molecular and cellular biochemistry · 2012Article
- Dynamic phosphometabolomic profiling of human tissues and transgenic models by 18O-assisted ³¹P NMR and mass spectrometry.Physiological genomics · 2012Article
- Creatine and pyruvate prevent behavioral and oxidative stress alterations caused by hypertryptophanemia in rats.Molecular and cellular biochemistry · 2012Article
- Compartmentation of membrane processes and nucleotide dynamics in diffusion-restricted cardiac cell microenvironment.Journal of molecular and cellular cardiology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The perpetual and vigorous nature of heart muscle work requires efficient myocardial energetics. This depends not only on adequate ATP production, but also on efficient delivery of ATP to muscle ATPases and rapid removal of ADP and other by-products of ATP hydrolysis. Indeed, recent evidence indicates that defects in communication between ATP-producing and ATP-consuming cellular sites are a major factor contributing to energetic deficiency in heart failure. In particular, the failing myocardium is characterized by reduced catalytic activity of creatine kinase, adenylate kinase, carbonic anhydrase, and glycolytic enzymes, which collectively facilitate ATP delivery and promote removal of ADP, Pi, and H+ from cellular ATPases. Although energy transfer through adenylate kinase and glycolytic enzymes has been recognized as an adaptive mechanism supporting compromised muscle energetics, in the failing myocardium the total compensatory potential of these systems is diminished. A gradual accumulation of defects at various steps in myocardial energetic signaling, along with compromised compensatory mechanisms, precipitates failure of the whole cardiac energetic system, ultimately contributing to myocardial dysfunction. These advances in our understanding of the molecular bioenergetics in heart failure provide a new perspective toward improving the energetic balance of the failing myocardium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.