ArticleOncogene2000
Correct binding of viral X protein to UVDDB-p127 cellular protein is critical for efficient infection by hepatitis B viruses.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 68 citations in OpenAlex.
- Novel Approaches to Inhibition of HBsAg Expression from cccDNA and Chromosomal Integrants: A Review.Journal of clinical and translational hepatology · 2023Review
- Tampering of Viruses and Bacteria with Host DNA Repair: Implications for Cellular Transformation.Cancers · 2021Review
- Article
- Restriction of hepatitis B virus replication by c-Abl-induced proteasomal degradation of the viral polymerase.Science advances · 2019Article
- Role of HBx in hepatitis B virus persistence and its therapeutic implications.Current opinion in virology · 2018Review
- Identifying and Characterizing Interplay between Hepatitis B Virus X Protein and Smc5/6.Viruses · 2017Review
- DDB1 Stimulates Viral Transcription of Hepatitis B Virus via HBx-Independent Mechanisms.Journal of virology · 2016Article
- Article
- Review
- Cullin E3 ligases and their rewiring by viral factors.Biomolecules · 2014Review
- The Tudor domain protein Spindlin1 is involved in intrinsic antiviral defense against incoming hepatitis B Virus and herpes simplex virus type 1.PLoS pathogens · 2014Article
- Hepatitis B virus regulatory HBx protein binding to DDB1 is required but is not sufficient for maximal HBV replication.Virology · 2012Article
- The hepatitis B virus x protein inhibits thymine DNA glycosylase initiated base excision repair.PloS one · 2012Article
- Hepatitis B and C virus hepatocarcinogenesis: lessons learned and future challenges.Cancer letters · 2011Review
- Hepatitis B virus regulatory HBx protein binds to adaptor protein IPS-1 and inhibits the activation of beta interferon.Journal of virology · 2011Article
- Replication of the hepatitis B virus requires a calcium-dependent HBx-induced G1 phase arrest of hepatocytes.Virology · 2010Article
- A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery.Nature structural & molecular biology · 2010Article
- Liver cell transformation in chronic HBV infection.Viruses · 2009Article
- Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Enhancement of hepatitis B virus replication by the regulatory X protein in vitro and in vivo.Journal of virology · 2007Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A fully effective treatment of chronic human hepatitis B virus (HBV) infection is still missing and HBV remains the first etiological agent of liver cancer. Although the viral regulatory X protein is essential for infection, its mode of action remains obscure, due the lack of an in vitro infection system. In the accompanying study, we showed the functional importance of interaction between X and the host protein UVDDB-p127, in the transactivation and apoptotic properties of the viral protein. Here, we addressed the biological role of X-UVDDB interaction in the infectious process using a genetic approach in the woodchuck virus closely related to HBV. We show that (i) mutations in X, which markedly affect UVDDB-binding, also abolished productive infection in woodchucks, (ii) in the few cases where mutant viruses led to infection, compensatory mutations had occurred in the X gene of the viral progeny, which restored correct UVDDB-binding. We conclude that efficient viral replication in vivo requires proper X-UVDDB interaction. The interaction may thus provide a novel therapeutic target for the treatment of hepatitis
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.