ArticleThe American journal of pathology2000
Astrocytes give rise to oligodendrogliomas and astrocytomas after gene transfer of polyoma virus middle T antigen in vivo.
Article in The American journal of pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 81 citations in OpenAlex.
- Advances in Immunocompetent Mouse and Rat Models.Cold Spring Harbor perspectives in medicine · 2024Review
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- Mammary Precancerous Stem and Non-Stem Cells Evolve into Cancers of Distinct Subtypes.Cancer research · 2019Article
- Luminal epithelial cells within the mammary gland can produce basal cells upon oncogenic stress.Oncogene · 2016Article
- Targeting Oncogenes into a Defined Subset of Mammary Cells Demonstrates That the Initiating Oncogenic Mutation Defines the Resulting Tumor Phenotype.International journal of biological sciences · 2016Article
- Oligodendrocyte/type-2 astrocyte progenitor cells and glial-restricted precursor cells generate different tumor phenotypes in response to the identical oncogenes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Current understanding of the role and targeting of tumor suppressor p53 in glioblastoma multiforme.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013Review
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- Bcl-2 promotes malignant progression in a PDGF-B-dependent murine model of oligodendroglioma.International journal of cancer · 2011Article
- Complex oncogenic signaling networks regulate brain tumor-initiating cells and their progenies: pivotal roles of wild-type EGFR, EGFRvIII mutant and hedgehog cascades and novel multitargeted therapies.Brain pathology (Zurich, Switzerland) · 2011Review
- Mesenchymal stem cells display tumor-specific tropism in an RCAS/Ntv-a glioma model.Neoplasia (New York, N.Y.) · 2011Article
- Epigenetic regulation of aging stem cells.Oncogene · 2011Review
- NG2-expressing glial precursor cells are a new potential oligodendroglioma cell initiating population in N-ethyl-N-nitrosourea-induced gliomagenesis.Carcinogenesis · 2010Article
- Somatic expression of PyMT or activated ErbB2 induces estrogen-independent mammary tumorigenesis.Neoplasia (New York, N.Y.) · 2010Article
- The RCAS-TVA system for introduction of oncogenes into selected somatic mammary epithelial cells in vivo.Journal of mammary gland biology and neoplasia · 2009Article
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- Design and application of oncolytic HSV vectors for glioblastoma therapy.Expert review of neurotherapeutics · 2009Review
- Glioma formation, cancer stem cells, and akt signaling.Stem cell reviews · 2008Review
- Trp53 deletion stimulates the formation of metastatic pancreatic tumors.The American journal of pathology · 2008Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cells of origin for oligodendrogliomas and astrocytomas are not known but are presumed to be oligodendrocyte and astrocyte precursors, respectively. In this paper we report the generation of mixed gliomas from in vivo transformation of glial fibrillary acidic protein (GFAP)-positive cells (differentiated astrocytes) with polyoma virus middle T antigen (MTA). MTA is a powerful oncogene that activates a number of signal transduction pathways, including those proposed to be involved in gliomagenesis, and has been shown to induce tumors in many cell types. We have achieved transfer of MTA expression specifically to GFAP(+) cells in vivo using somatic cell gene transfer, and find resultant formation of anaplastic gliomas with mixed astrocytoma and oligodendroglioma morphological features. We conclude that GFAP- expressing astrocytes, with appropriate signaling abnormalities, can serve as the cell of origin for oligodendrogliomas, astrocytomas, or mixed gliomas.
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