ArticleThe American journal of pathology2000
PAX2 suppresses apoptosis in renal collecting duct cells.
Article in The American journal of pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 97 citations in OpenAlex.
- Pax proteins mediate segment-specific functions in proximal tubule survival and response to ischemic injury.American journal of physiology. Renal physiology · 2025Article
- Pax protein depletion in proximal tubules triggers conserved mechanisms of resistance to acute ischemic kidney injury preventing transition to chronic kidney disease.Kidney international · 2024Article
- Factors influencing the development of Multicystic Dysplastic Kidney (MCDK) following urinary tract obstruction in the fetal lamb.Pediatric surgery international · 2022Article
- PHD3 inhibits cell proliferation through hydroxylation of PAX2 at proline 9.Acta biochimica et biophysica Sinica · 2022Article
- Pax2a, but not pax2b, influences cell survival and periocular mesenchyme localization to facilitate zebrafish optic fissure closure.Developmental dynamics : an official publication of the American Association of Anatomists · 2022Article
- Identification of candidate PAX2-regulated genes implicated in human kidney development.Scientific reports · 2021Article
- Doxycycline Changes the Transcriptome Profile of mIMCD3 Renal Epithelial Cells.Frontiers in physiology · 2021Article
- PAX2 maintains the differentiation of mouse oviductal epithelium and inhibits the transition to a stem cell-like state.Oncotarget · 2017Article
- Association of PAX2 and Other Gene Mutations with the Clinical Manifestations of Renal Coloboma Syndrome.PloS one · 2015Article
- Genome-wide analysis of gestational gene-environment interactions in the developing kidney.Physiological genomics · 2014Article
- Kidney regeneration: common themes from the embryo to the adult.Pediatric nephrology (Berlin, Germany) · 2014Review
- The impact of maternal cigarette smoke exposure in a rodent model on renal development in the offspring.PloS one · 2014Article
- Deregulation of PAX2 expression in renal cell tumours: mechanisms and potential use in differential diagnosis.Journal of cellular and molecular medicine · 2013Article
- Pax8 has a critical role in epithelial cell survival and proliferation.Cell death & disease · 2013Article
- PAX2 protein induces expression of cyclin D1 through activating AP-1 protein and promotes proliferation of colon cancer cells.The Journal of biological chemistry · 2012Article
- Increased hedgehog signaling in postnatal kidney results in aberrant activation of nephron developmental programs.Human molecular genetics · 2011Article
- PAX2 regulates ADAM10 expression and mediates anchorage-independent cell growth of melanoma cells.PloS one · 2011Article
- PAX2 expression in low malignant potential ovarian tumors and low-grade ovarian serous carcinomas.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2009Article
- Pax genes in embryogenesis and oncogenesis.Journal of cellular and molecular medicine · 2008Review
- WNT5A is regulated by PAX2 and may be involved in blastemal predominant Wilms tumorigenesis.Neoplasia (New York, N.Y.) · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PAX2 is a transcription factor belonging to the evolutionarily conserved paired box family and is required during development of the central nervous system and genitourinary axis. Mutations in the PAX2 gene cause a rare autosomal dominant renal-coloboma syndrome, characterized by optic nerve colobomas and renal hypoplasia. Recent analysis of a spontaneous PAX2 mutant mouse model (1Neu) revealed that the major cause of renal hypoplasia is reduced branching of the ureteric bud (UB) and fewer nephrons. We have observed that this abnormality is associated with a striking increase in the number of UB cells undergoing programmed cell death during nephrogenesis. To ascertain whether apoptosis is directly linked to the level of PAX2 expression, we have studied the role of PAX2 in cultured renal cells. We show that mIMCD-3 cells, a murine collecting duct cell line with high endogenous PAX2 expression, undergo apoptosis when transfected with anti-sense PAX2. In contrast, HEK293 cells expressing exogenous PAX2 are protected against apoptotic death induced by caspase-2. PAX2 has no effect on proliferation of embryonic kidney or in cultured kidney cells. Our observations imply a direct role for PAX2 in survival of ureteric bud cells.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.