ArticleThe American journal of pathology2000
Highly invasive transitional cell carcinoma of the bladder in a simian virus 40 T-antigen transgenic mouse model.
Article in The American journal of pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 73 citations in OpenAlex.
- Bioprinted research models of urological malignancy.Exploration (Beijing, China) · 2024Review
- Perspective: Humanized Pig Models of Bladder Cancer.Frontiers in molecular biosciences · 2021Article
- Article
- Association Between Simian Virus 40 and Human Tumors.Frontiers in oncology · 2019Review
- Modeling human bladder cancer.World journal of urology · 2018Review
- Polyoma virus-associated carcinomas of the urologic tract: a clinicopathologic and molecular study.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Article
- Molecular Subtype-Specific Immunocompetent Models of High-Grade Urothelial Carcinoma Reveal Differential Neoantigen Expression and Response to Immunotherapy.Cancer research · 2018Article
- BK virus-associated collecting duct carcinoma of the renal allograft in a kidney-pancreas allograft recipient.Oncotarget · 2018Article
- Understanding the biology of urothelial cancer metastasis.Asian journal of urology · 2016Review
- Regulation of Cellular Identity in Cancer.Developmental cell · 2015Review
- Modelling bladder cancer in mice: opportunities and challenges.Nature reviews. Cancer · 2015Review
- Current animal models of bladder cancer: Awareness of translatability (Review).Experimental and therapeutic medicine · 2014Article
- Development and characterization of a preclinical model of breast cancer lung micrometastatic to macrometastatic progression.PloS one · 2014Article
- p53-stabilizing agent CP-31398 prevents growth and invasion of urothelial cancer of the bladder in transgenic UPII-SV40T mice.Neoplasia (New York, N.Y.) · 2013Article
- MALAT1 -- a paradigm for long noncoding RNA function in cancer.Journal of molecular medicine (Berlin, Germany) · 2013Review
- Genetic and pharmacologic inhibition of complement impairs endothelial cell function and ablates ovarian cancer neovascularization.Neoplasia (New York, N.Y.) · 2012Article
- Exploring molecular genetics of bladder cancer: lessons learned from mouse models.Disease models & mechanisms · 2012Review
- Stromal modulation of bladder cancer-initiating cells in a subcutaneous tumor model.American journal of cancer research · 2012Article
- Simian virus 40 transformation, malignant mesothelioma and brain tumors.Expert review of respiratory medicine · 2011Review
- Development of a syngeneic mouse model of epithelial ovarian cancer.Journal of ovarian research · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Transitional cell carcinoma (TCC), a neoplasm of urinary bladder urothelial cells, generally appears in either of two forms, papillary non-invasive or invasive TCC, although intermediate forms can occur. Each has a distinctive morphology and clinical course. Altered expression of the p53 and pRb genes has been associated with the more serious invasive TCC, suggesting that the loss of activity of these tumor suppressor proteins may have a causal role in this disease. To test this hypothesis directly, transgenic mice were developed that expressed the simian virus 40 large T antigen (TAg) in urothelial cells under the control of the cytokeratin 19 gene (CK19) regulatory elements. In one CK19-TAg lineage, all transgenic mice developed highly invasive bladder neoplasms that resembled invasive human bladder TCCs. Stages of disease progression included development of carcinoma in situ, stromal invasion, muscle invasion, rapid growth, and, in 20% of affected mice, intravascular lung metastasis. Papillary lesions never were observed. Western blot analysis indicated that TAg was bound to both p53 and pRb, which has been shown to cause inactivation of these proteins. Our findings support suggestions that (i) inactivation of p53 and/or pRb constitutes a causal step in the etiology of invasive TCC, (ii) papillary and invasive TCC may have different molecular causes, and (iii) carcinoma in situ can represent an early stage in the progression to invasive TCC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.