ArticleThe American journal of pathology2000
Hepatocyte growth factor secreted by prostate-derived stromal cells stimulates growth of androgen-independent human prostatic carcinoma cells.
Article in The American journal of pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 51 citations in OpenAlex.
- Resveratrol Suppresses Prostate Cancer Epithelial Cell Scatter/Invasion by Targeting Inhibition of Hepatocyte Growth Factor (HGF) Secretion by Prostate Stromal Cells and Upregulation of E-cadherin by Prostate Cancer Epithelial Cells.International journal of molecular sciences · 2020Article
- Spatially restricted Hedgehog signalling regulates HGF-induced branching of the adult prostate.Nature cell biology · 2014Article
- Circulating fibroblast-like cells in men with metastatic prostate cancer.The Prostate · 2013Article
- Prostate cancer-derived angiogenin stimulates the invasion of prostate fibroblasts.Journal of cellular and molecular medicine · 2012Article
- Differences in phenotype and gene expression of prostate stromal cells from patients of varying ages and their influence on tumour formation by prostate epithelial cells.Asian journal of andrology · 2011Article
- Prostate tumor cell plasticity: a consequence of the microenvironment.Advances in experimental medicine and biology · 2011Review
- Expression of TRPC6 in benign and malignant human prostate tissues.Asian journal of andrology · 2009Article
- [Development of a three-dimensional primary prostate cancer cell culture model].Der Urologe. Ausg. A · 2008Article
- Telomere attrition in isolated high-grade prostatic intraepithelial neoplasia and surrounding stroma is predictive of prostate cancer.Neoplasia (New York, N.Y.) · 2007Article
- Catalytically inactive human cathepsin D triggers fibroblast invasive growth.The Journal of cell biology · 2005Article
- Phenotypic switch from paracrine to autocrine role of hepatocyte growth factor in an androgen-independent human prostatic carcinoma cell line, CWR22R.The American journal of pathology · 2004Article
- SF/HGF-c-Met autocrine and paracrine promote metastasis of hepatocellular carcinoma.World journal of gastroenterology · 2001Article
- Normal and malignant prostate epithelial cells differ in their response to hepatocyte growth factor/scatter factor.The American journal of pathology · 2001Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The objective of the present study is to examine the role of prostate stromal cells on growth and progression of prostate cancer. Co-inoculation of androgen-independent carcinoma cells (PC-3 and CA-7T2) with prostate-derived stromal (P-ST) cells significantly enhanced the growth of carcinoma cells in athymic nude mice. For the in vitro study, a three-dimensional co-culture system was used. It consisted of two layers of collagen gel. Stromal cells were suspended in the lower layer, whereas cancer cells were suspended in the upper layer. Compared to the control culture, the presence of P-ST cells in the lower collagen layer significantly stimulated the growth of carcinoma cells. Such an effect was not demonstrated when carcinoma cells were co-cultured with either bone marrow-derived or skin-derived stromal cells. We identified hepatocyte growth factor (HGF) as the principal growth factor released by P-ST cells but not by bone marrow-derived or skin-derived stromal cells. Neutralizing antibodies against HGF completely abrogated the stimulatory effect of P-ST cells. Exogenous HGF likewise stimulated the growth of carcinoma cells in vitro and in vivo. These results suggest that HGF produced by P-ST cells is a paracrine growth factor that stimulates the growth of androgen-independent prostate cancer cell lines.
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