ArticleJournal of medical genetics2000
Genetics of club foot in Maori and Pacific people.
Article in Journal of medical genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- The etiology of idiopathic congenital talipes equinovarus: a systematic review.Journal of orthopaedic surgery and research · 2018Pooled it
- Determinants for Congenital Clubfoot in Ethiopia: A Case-Control Study at Black Lion Specialized Hospital.Health science reports · 2026Article
- Review
- Assessment of the COL9A1 Single Nucleotide Polymorphism with Severity of clubfoot in a paediatric population along with their biological mothers.Journal of clinical orthopaedics and trauma · 2022Article
- Analysis OF C677T polymorphism in methylene tetrahydrofolate reductase (MTHFR) gene as a risk factor for congenital talipes equino varus (CTEV).Journal of clinical orthopaedics and trauma · 2021Article
- Clubfoot deformity in the Solomon Islands: MelanesianJournal of children's orthopaedics · 2020Article
- The genetics of isolated and syndromic clubfoot.Journal of children's orthopaedics · 2019Article
- The developmental and genetic basis of 'clubfoot' in the peroneal muscular atrophy mutant mouse.Development (Cambridge, England) · 2018Article
- The recurrence risk of genetic complex diseases.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2017Review
- A systematic review of association studies of common variants associated with idiopathic congenital talipes equinovarus (ICTEV) in humans in the past 30 years.SpringerPlus · 2016Review
- The embryonic myosin R672C mutation that underlies Freeman-Sheldon syndrome impairs cross-bridge detachment and cycling in adult skeletal muscle.Human molecular genetics · 2015Article
- Celsr3 is required in motor neurons to steer their axons in the hindlimb.Nature neuroscience · 2014Article
- Apoptotic genes expression in placenta of clubfoot-like fetus pregnant rats.International journal of clinical and experimental pathology · 2014Article
- Copy number analysis of 413 isolated talipes equinovarus patients suggests role for transcriptional regulators of early limb development.European journal of human genetics : EJHG · 2013Article
- Congenital talipes equinovarus: an epidemiological study in Sicily.Acta orthopaedica · 2012Article
- Descriptive epidemiology of clubfoot in Vietnam: a clinic-based study.The Iowa orthopaedic journal · 2012Article
- Article
- The expression of Gli3, regulated by HOXD13, may play a role in idiopathic congenital talipes equinovarus.BMC musculoskeletal disorders · 2009Article
- Evaluation of CAND2 and WNT7a as candidate genes for congenital idiopathic clubfoot.Clinical orthopaedics and related research · 2009Article
- Update on clubfoot: etiology and treatment.Clinical orthopaedics and related research · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of major gene and multifactorial inheritance in the aetiology of club foot in the New Zealand Polynesian population was studied using 287 New Zealand Maori and Pacific club foot families. The club foot family data were analysed by complex segregation analysis under the mixed model using the computer program POINTER. This analysis shows that the best genetic model for club foot in this population is a single dominant gene with a penetrance of 33% and a predicted gene frequency of 0.9%. These data provide a scientific foundation for molecular studies in the Maori and Polynesian population to identify putative club foot genes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.