ArticleGenetics2000
Contrasting patterns of nonneutral evolution in proteins encoded in nuclear and mitochondrial genomes.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 124 citations in OpenAlex.
- Hill-Robertson interference may bias the inference of fitness effects of new mutations in highly selfing species.Evolution; international journal of organic evolution · 2025Article
- Hill-Robertson interference may bias the inference of fitness effects of new mutations in highly selfing species.bioRxiv : the preprint server for biology · 2024Article
- Population genetic structure and historical demography of the population of forest elephants in Côte d'Ivoire.PloS one · 2024Article
- Impact of climate change on parasite infection of an important pollinator depends on host genotypes.Global change biology · 2023Article
- The population genomics of adaptive loss of function.Heredity · 2021Review
- Population Genetics of Paramecium Mitochondrial Genomes: Recombination, Mutation Spectrum, and Efficacy of Selection.Genome biology and evolution · 2019Article
- The on-again, off-again relationship between mitochondrial genomes and species boundaries.Molecular ecology · 2017Review
- Animal Mitochondrial DNA as We Do Not Know It: mt-Genome Organization and Evolution in Nonbilaterian Lineages.Genome biology and evolution · 2016Article
- Similar Efficacies of Selection Shape Mitochondrial and Nuclear Genes in Both Drosophila melanogaster and Homo sapiens.G3 (Bethesda, Md.) · 2015Article
- Inference of purifying and positive selection in three subspecies of chimpanzees (Pan troglodytes) from exome sequencing.Genome biology and evolution · 2015Article
- Domestication and the mitochondrial genome: comparing patterns and rates of molecular evolution in domesticated mammals and birds and their wild relatives.Genome biology and evolution · 2014Article
- Weak selection and protein evolution.Genetics · 2012Review
- Mitochondrial-nuclear epistasis: implications for human aging and longevity.Ageing research reviews · 2011Review
- Genomic determinants of protein evolution and polymorphism in Arabidopsis.Genome biology and evolution · 2011Article
- The role of the effective population size in compensatory evolution.Genome biology and evolution · 2011Article
- Effective population size and the efficacy of selection on the X chromosomes of two closely related Drosophila species.Genome biology and evolution · 2011Article
- Mitochondrial pathogenic mutations are population-specific.Biology direct · 2010Article
- Gene genealogies strongly distorted by weakly interfering mutations in constant environments.Genetics · 2010Article
- Pervasive natural selection in the Drosophila genome?PLoS genetics · 2009Article
- Molecular evolution of the Bovini tribe (Bovidae, Bovinae): is there evidence of rapid evolution or reduced selective constraint in Domestic cattle?BMC genomics · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report that patterns of nonneutral DNA sequence evolution among published nuclear and mitochondrially encoded protein-coding loci differ significantly in animals. Whereas an apparent excess of amino acid polymorphism is seen in most (25/31) mitochondrial genes, this pattern is seen in fewer than half (15/36) of the nuclear data sets. This differentiation is even greater among data sets with significant departures from neutrality (14/15 vs. 1/6). Using forward simulations, we examined patterns of nonneutral evolution using parameters chosen to mimic the differences between mitochondrial and nuclear genetics (we varied recombination rate, population size, mutation rate, selective dominance, and intensity of germ line bottleneck). Patterns of evolution were correlated only with effective population size and strength of selection, and no single genetic factor explains the empirical contrast in patterns. We further report that in Arabidopsis thaliana, a highly self-fertilizing plant with effectively low recombination, five of six published nuclear data sets also exhibit an excess of amino acid polymorphism. We suggest that the contrast between nuclear and mitochondrial nonneutrality in animals stems from differences in rates of recombination in conjunction with a distribution of selective effects. If the majority of mutations segregating in populations are deleterious, high linkage may hinder the spread of the occasional beneficial mutation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.