ArticleGenetics2000
A genome-wide departure from the standard neutral model in natural populations of Drosophila.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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Who cites it
86 citing papers in PubMed.
- Causal inference clarifies the roles of background selection and mutation rate variation in shaping human genetic diversity.bioRxiv : the preprint server for biology · 2026Article
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- Detection of hard and soft selective sweeps from Drosophila melanogaster population genomic data.PLoS genetics · 2021Article
- Elevated Linkage Disequilibrium and Signatures of Soft Sweeps Are Common in Drosophila melanogaster.Genetics · 2016Article
- An Approximate Markov Model for the Wright-Fisher Diffusion and Its Application to Time Series Data.Genetics · 2016Article
- Genomic signatures of population decline in the malaria mosquito Anopheles gambiae.Malaria journal · 2016Article
- Secondary contact and local adaptation contribute to genome-wide patterns of clinal variation in Drosophila melanogaster.Molecular ecology · 2016Article
- Deep Learning for Population Genetic Inference.PLoS computational biology · 2016Article
- Whole-genome sequence analyses of Western Central African Pygmy hunter-gatherers reveal a complex demographic history and identify candidate genes under positive natural selection.Genome research · 2016Article
- Simple Biophysical Model Predicts Faster Accumulation of Hybrid Incompatibilities in Small Populations Under Stabilizing Selection.Genetics · 2015Article
- Nucleotide Sequence Diversity and Linkage Disequilibrium of Four Nuclear Loci in Foxtail Millet (Setaria italica).PloS one · 2015Article
- Evaluating the ability of the pairwise joint site frequency spectrum to co-estimate selection and demography.Frontiers in genetics · 2015Article
- Article
- Detecting selection in the blue crab, Callinectes sapidus, using DNA sequence data from multiple nuclear protein-coding genes.PloS one · 2014Article
- Why to account for finite sites in population genetic studies and how to do this with Jaatha 2.0.Ecology and evolution · 2013Article
- A selective sweep across species boundaries in Drosophila.Molecular biology and evolution · 2013Article
- Signatures of demography and recombination at coding genes in naturally-distributed populations of Arabidopsis lyrata subsp. petraea.PloS one · 2013Article
- Estimating divergence dates and substitution rates in the Drosophila phylogeny.Molecular biology and evolution · 2012Article
- Review
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26 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We analyze nucleotide polymorphism data for a large number of loci in areas of normal to high recombination in Drosophila melanogaster and D. simulans (24 and 16 loci, respectively). We find a genome-wide, systematic departure from the neutral expectation for a panmictic population at equilibrium in natural populations of both species. The distribution of sequence-based estimates of 2Nc across loci is inconsistent with the assumptions of the standard neutral theory, given the observed levels of nucleotide diversity and accepted values for recombination and mutation rates. Under these assumptions, most estimates of 2Nc are severalfold too low; in other words, both species exhibit greater intralocus linkage disequilibrium than expected. Variation in recombination or mutation rates is not sufficient to account for the excess of linkage disequilibrium. While an equilibrium island model does not seem to account for the data, more complicated forms of population structure may. A proper test of alternative demographic models will require loci to be sampled in a more consistent fashion.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.