ArticleGenetics2000
Molecular population genetics of X-linked genes in Drosophila pseudoobscura.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 52 citations in OpenAlex.
- A population genomic resource for Drosophila pseudoobscura.G3 (Bethesda, Md.) · 2026Article
- Population genomics ofbioRxiv : the preprint server for biology · 2026Article
- Evolutionary robustness of killer meiotic drives.Evolution letters · 2021Article
- Resistance to natural and synthetic gene drive systems.Journal of evolutionary biology · 2020Review
- Ancient gene drives: an evolutionary paradox.Proceedings. Biological sciences · 2019Article
- Meiotic drive reduces egg-to-adult viability in stalk-eyed flies.Proceedings. Biological sciences · 2019Article
- Ejaculate sperm number compensation in stalk-eyed flies carrying a selfish meiotic drive element.Heredity · 2019Article
- How chromosomal rearrangements shape adaptation and speciation: Case studies in Drosophila pseudoobscura and its sibling species Drosophila persimilis.Molecular ecology · 2019Article
- Ancestral polymorphisms explain the role of chromosomal inversions in speciation.PLoS genetics · 2018Article
- Contrasting patterns of X-chromosome divergence underlie multiple sex-ratio polymorphisms in stalk-eyed flies.Journal of evolutionary biology · 2017Article
- Occasional recombination of a selfish X-chromosome may permit its persistence at high frequencies in the wild.Journal of evolutionary biology · 2016Article
- Article
- Mistaken Identity: Another Bias in the Use of Relative Genetic Divergence Measures for Detecting Interspecies Introgression.PloS one · 2016Article
- Sex chromosome drive.Cold Spring Harbor perspectives in biology · 2014Review
- Evidence for stabilizing selection on codon usage in chromosomal rearrangements of Drosophila pseudoobscura.G3 (Bethesda, Md.) · 2014Article
- Recent selection on the Y-to-dot translocation in Drosophila pseudoobscura.Molecular biology and evolution · 2014Article
- Gene flow and gene flux shape evolutionary patterns of variation in Drosophila subobscura.Heredity · 2013Article
- Within-niche constant selection of Drosophila inversions?Scientifica · 2012Article
- Sequence Analysis of the Segmental Duplication Responsible for Paris Sex-Ratio Drive in Drosophila simulans.G3 (Bethesda, Md.) · 2011Article
- Chromosome-wide linkage disequilibrium caused by an inversion polymorphism in the white-throated sparrow (Zonotrichia albicollis).Heredity · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This article presents a nucleotide sequence analysis of 500 bp determined in each of five X-linked genes, runt, sisterlessA, period, esterase 5, and Heat-shock protein 83, in 40 Drosophila pseudoobscura strains collected from two populations. Estimates of the neutral migration parameter for the five loci show that gene flow among D. pseudoobscura populations is sufficient to homogenize inversion frequencies across the range of the species. Nucleotide diversity at each locus fails to reject a neutral model of molecular evolution. The sample of 40 chromosomes included six Sex-ratio inversions, a series of three nonoverlapping inversions that are associated with a strong meiotic drive phenotype. The selection driven by the Sex-ratio meiotic drive element has not fixed variation across the X chromosome of D. pseudoobscura because, while significant linkage disequilibrium was observed within the sisterlessA, period, and esterase 5 genes, we did not find evidence for nonrandom association among loci. The Sex-ratio chromosome was estimated to be 25,000 years old based on the decomposition of linkage disequilibrium between esterase 5 and Heat-shock protein 83 or 1 million years old based on the net divergence of esterase 5 between Standard and Sex-ratio chromosomes. Genetic diversity was depressed within esterase 5 within Sex-ratio chromosomes, while the four other genes failed to show a reduction in heterozygosity in the Sex-ratio background. The reduced heterogeneity in esterase 5 is due either to its location near one of the Sex-ratio inversion breakpoints or that it is closely linked to a gene or genes responsible for the Sex-ratio meiotic drive system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.