ArticleGenetics2000
Pep3p/Pep5p complex: a putative docking factor at multiple steps of vesicular transport to the vacuole of Saccharomyces cerevisiae.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 65 citations in OpenAlex.
- Protein Homeostasis Networks and the Use of Yeast to Guide Interventions in Alzheimer's Disease.International journal of molecular sciences · 2020Review
- The road to lysosome-related organelles: Insights from Hermansky-Pudlak syndrome and other rare diseases.Traffic (Copenhagen, Denmark) · 2019Review
- Control of vacuole membrane homeostasis by a resident PI-3,5-kinase inhibitor.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Expression of RING Finger Protein 38 in Serotonergic Neurons in the Brain of Nile Tilapia,Frontiers in neuroanatomy · 2018Article
- A High Copy Suppressor Screen for Autophagy Defects inG3 (Bethesda, Md.) · 2017Article
- RING Finger Protein 38 Is a Neuronal Protein in the Brain of Nile Tilapia,Frontiers in neuroanatomy · 2017Article
- Article
- Vesicular Trafficking Systems Impact TORC1-Controlled Transcriptional Programs in Saccharomyces cerevisiae.G3 (Bethesda, Md.) · 2016Article
- Components of Golgi-to-vacuole trafficking are required for nitrogen- and TORC1-responsive regulation of the yeast GATA factors.MicrobiologyOpen · 2014Article
- Article
- Article
- Novel E3 ubiquitin ligases that regulate histone protein levels in the budding yeast Saccharomyces cerevisiae.PloS one · 2012Article
- The loss of vacuolar protein sorting 11 (vps11) causes retinal pathogenesis in a vertebrate model of syndromic albinism.Investigative ophthalmology & visual science · 2011Article
- Subunit organization and Rab interactions of Vps-C protein complexes that control endolysosomal membrane traffic.Molecular biology of the cell · 2011Article
- The CORVET subunit Vps8 cooperates with the Rab5 homolog Vps21 to induce clustering of late endosomal compartments.Molecular biology of the cell · 2009Article
- SPE-39 family proteins interact with the HOPS complex and function in lysosomal delivery.Molecular biology of the cell · 2009Article
- Rapamycin bypasses vesicle-mediated signaling events to activate Gln3 in Saccharomyces cerevisiae.Communicative & integrative biology · 2008Article
- Nuclear translocation of Gln3 in response to nutrient signals requires Golgi-to-endosome trafficking in Saccharomyces cerevisiae.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae.Genetics · 2007Article
- Purification of active HOPS complex reveals its affinities for phosphoinositides and the SNARE Vam7p.The EMBO journal · 2006Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Pep3p and Pep5p are known to be necessary for trafficking of hydrolase precursors to the vacuole and for vacuolar biogenesis. These proteins are present in a hetero-oligomeric complex that mediates transport at the vacuolar membrane. PEP5 interacts genetically with VPS8, implicating Pep5p in the earlier Golgi to endosome step and/or in recycling from the endosome to the Golgi. To understand further the cellular roles of Pep3p and Pep5p, we isolated and characterized a set of pep3 conditional mutants. Characterization of mutants revealed that pep3(ts) mutants are defective in the endosomal and nonendosomal Golgi to vacuole transport pathways, in the cytoplasm to vacuole targeting pathway, in recycling from the endosome back to the late Golgi, and in endocytosis. PEP3 interacts genetically with two members of the endosomal SNARE complex, PEP12 (t-SNARE) and PEP7 (homologue of mammalian EEA1); Pep3p and Pep5p associate physically with Pep7p as revealed by two-hybrid analysis. Our results suggest that a core Pep3p/Pep5p complex promotes vesicular docking/fusion reactions in conjunction with SNARE proteins at multiple steps in transport routes to the vacuole. We propose that this complex may be responsible for tethering transport vesicles on target membranes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.