Evidence map›Paper›PMID 10974128›Full record

ReviewMicrobiology and molecular biology reviews : MMBR2000

Lytic cycle of Toxoplasma gondii.

M W Black, J C Boothroyd

Abstract readReview
In one paragraph

Review in Microbiology and molecular biology reviews : MMBR, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 228 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
228citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

228 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
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  12. Bioactive materials · 2025
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  15. Article
  16. Article
  17. mBio · 2025
    Article
  18. Article
  19. Article
  20. Article

168 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

M W BlackDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305-5124, USA.
J C Boothroyd

Funding

Toxoplasma Rhoptry FunctionR01AI021423 · NIAID · STANFORD UNIVERSITY · PI BOOTHROYD, JOHN C · 1985 to 2018
$7.8M
ANTIGENS OF TOXOPLASMA GONDII AND THEIR GENESR37AI021423 · NIAID · STANFORD UNIVERSITY · PI BOOTHROYD, JOHN C · 1994 to 2003
$1.6M
GENETICS OF INVASION AND EGRESS IN TOXOPLASMAR01AI045057 · NIAID · STANFORD UNIVERSITY · PI BOOTHROYD, JOHN C · 1999 to 2003
$1.1M
NIAID NIH HHS AI21423NIAID NIH HHS AI45057NIAID NIH HHS R01 AI021423NIAID NIH HHS R01 AI045057NIAID NIH HHS R37 AI021423
6 · The paper itself

Abstract

Toxoplasma gondii is an obligate intracellular pathogen within the phylum Apicomplexa. This protozoan parasite is one of the most widespread, with a broad host range including many birds and mammals and a geographic range that is nearly worldwide. While infection of healthy adults is usually relatively mild, serious disease can result in utero or when the host is immunocompromised. This sophisticated eukaryote has many specialized features that make it well suited to its intracellular lifestyle. In this review, we describe the current knowledge of how the asexual tachyzoite stage of Toxoplasma attaches to, invades, replicates in, and exits the host cell. Since this process is closely analogous to the way in which viruses reproduce, we refer to it as the Toxoplasma "lytic cycle."

Indexed as

AnimalsHumansLife Cycle StagesReproductionToxoplasmaToxoplasmosisToxoplasmosis, Animal

Identifiers

PMID10974128
PMCPMC99006

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.