Genetic and environmental effects in paroxysmal nocturnal hemoglobinuria: this little PIG-A goes "Why? Why? Why?".

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

26 citing papers in PubMed, 94 citations in OpenAlex.

1. Hairy Cell Leukemia: A Differential Diagnosis of Hepatitis B-Associated Aplastic Anemia and Syphilis.Hematology reports · 2025
   Article
2. Reference guide for the diagnosis of adult primary immune thrombocytopenia, 2023 edition.International journal of hematology · 2024
   Article
3. Clinical and Molecular Determinants of Clonal Evolution in Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023
   Article
4. Clonality in immune aplastic anemia: Mechanisms of immune escape or malignant transformation.Seminars in hematology · 2022
   Review
5. Hypoplastic myelodysplastic syndrome and acquired aplastic anemia: Immune‑mediated bone marrow failure syndromes (Review).International journal of oncology · 2022
   Review
6. The similarity of class II HLA genotypes defines patterns of autoreactivity in idiopathic bone marrow failure disorders.Blood · 2021
   Article
7. Idiopathic aplastic anemia vs hypocellular myelodysplastic syndrome.Hematology. American Society of Hematology. Education Program · 2019
   Article
8. CRISPR/Cas9Blood · 2019
   Article
9. The evolution of paroxysmal nocturnal haemoglobinuria depends on intensity of immunosuppressive therapy.British journal of haematology · 2018
   Article
10. Expanding Complement Therapeutics for the Treatment of Paroxysmal Nocturnal Hemoglobinuria.Seminars in hematology · 2018
    Review
11. Clinical implications of somatic mutations in aplastic anemia and myelodysplastic syndrome in genomic age.Hematology. American Society of Hematology. Education Program · 2017
    Review
12. Paroxysmal nocturnal haemoglobinuria.Nature reviews. Disease primers · 2017
    Review
13. Complement in paroxysmal nocturnal hemoglobinuria: exploiting our current knowledge to improve the treatment landscape.Expert review of hematology · 2014
    Review
14. Anti-Complement Treatment in Paroxysmal Nocturnal Hemoglobinuria: Where we Stand and Where we are Going.Translational medicine @ UniSa · 2014
    Article
15. Immunologic aspects of hypoplastic myelodysplastic syndrome.Seminars in oncology · 2011
    Review
16. Deletions of Xp22.2 including PIG-A locus lead to paroxysmal nocturnal hemoglobinuria.Leukemia · 2011
    Article
17. Paroxysmal nocturnal hemoglobinuria: pathophysiology, natural history and treatment options in the era of biological agents.Biologics : targets & therapy · 2008
    Article
18. Clonality of the stem cell compartment during evolution of myelodysplastic syndromes and other bone marrow failure syndromes.Leukemia · 2007
    Review
19. Paroxysmal nocturnal hemoglobinuria in children.Paediatric drugs · 2007
    Review
20. Molecular basis of clonal expansion of hematopoiesis in 2 patients with paroxysmal nocturnal hemoglobinuria (PNH).Blood · 2006
    Article

Corrections and comments

• Comment on
  Impaired growth and elevated fas receptor expression in PIGA(+) stem cells in primary paroxysmal nocturnal hemoglobinuria.2000

Authors and funding

2 authors at 2 institutions in 1 country.

Funding

Abstract

PubMed holds no abstract for this paper.

Indexed as