ArticleProceedings of the National Academy of Sciences of the United States of America2000
Assessment and discrimination of odor stimuli in rat olfactory bulb by dynamic functional MRI.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 127 citations in OpenAlex.
- Awake rodent fMRI: Gradient-echo echo planar imaging versus compressed-sensing fast low-angle shot.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Differential functional change in olfactory bulb and olfactory eloquent areas in Parkinson's disease.Brain communications · 2024Article
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- A comparative neuroimaging perspective of olfaction and higher-order olfactory processing: on health and disease.Seminars in cell & developmental biology · 2022Review
- Olfactory Information Storage Engages Subcortical and Cortical Brain Regions That Support Valence Determination.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Thalamic activations in rat brain by fMRI during tactile (forepaw, whisker) and non-tactile (visual, olfactory) sensory stimulations.PloS one · 2022Article
- Functional Activities Detected in the Olfactory Bulb and Associated Olfactory Regions in the Human Brain Using T2-Prepared BOLD Functional MRI at 7T.Frontiers in neuroscience · 2021Article
- Article
- Foundations of layer-specific fMRI and investigations of neurophysiological activity in the laminarized neocortex and olfactory bulb of animal models.NeuroImage · 2019Review
- Article
- Mesoscopic and microscopic imaging of sensory responses in the same animal.Nature communications · 2019Article
- Single compounds elicit complex behavioural responses in wild, free-ranging rats.Scientific reports · 2018Article
- fMRI study of the role of glutamate NMDA receptor in the olfactory processing in monkeys.PloS one · 2018Article
- Activity Patterns Elicited by Airflow in the Olfactory Bulb and Their Possible Functions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Article
- Visualization of the olfactory nerve using constructive interference in steady state magnetic resonance imaging.Surgical and radiologic anatomy : SRA · 2017Article
- In vivo imaging techniques: a new era for histochemical analysis.European journal of histochemistry : EJH · 2016Review
- Comparison of glomerular activity patterns by fMRI and wide-field calcium imaging: Implications for principles underlying odor mapping.NeuroImage · 2016Article
- Layer-Specific fMRI Responses to Excitatory and Inhibitory Neuronal Activities in the Olfactory Bulb.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Insights from neuroenergetics into the interpretation of functional neuroimaging: an alternative empirical model for studying the brain's support of behavior.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Dynamic blood oxygenation level-dependent functional MRI was applied at 7 T in the rat olfactory bulb (OB) with pulsed delivery of iso-amyl acetate (IAA) and limonene. Acquisition times for single-slice and whole OB data were 8 and 32 s, respectively, with spatial resolution of 220 x 220 x 250 micrometer. On an intrasubject basis, short IAA exposures of 0.6 min separated by 3.5-min intervals induced reproducible spatial activity patterns (SAPs) in the olfactory nerve layer, glomerular layer, and external plexiform layer. During long exposures ( approximately 10 min), the initially dominant dorsal SAPs declined in intensity and area, whereas in some OB regions, the initially weak ventral/lateral SAPs increased first and then decreased. The SAPs of different concentrations were topologically similar, which implies that whereas an odor at various concentrations activates the same subsets of receptor cells, different concentrations are assessed and discriminated by variable magnitudes of laminarspecific activations. IAA and limonene reproducibly activated different subsets of receptor cells with some overlaps. Whereas qualitative topographical agreement was observed with results from other methods, the current dynamic blood oxygenation level-dependent functional MRI results can provide quantitative SAPs of the entire OB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.