ArticleGlycoconjugate journal1999
Haptoglobin glycoforms in a case of carbohydrate-deficient glycoprotein syndrome.
Article in Glycoconjugate journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Extensive Hypoglycosylation of Serum N-Glycoproteins in SRD5A3 Deficiency.Journal of inherited metabolic disease · 2026Article
- A complement C4-derived glycopeptide is a biomarker for PMM2-CDG.JCI insight · 2024Article
- Changes in glycosylation of human blood plasma chitotriosidase in patients with type 2 diabetes.Glycoconjugate journal · 2016Article
- Differences between the glycosylation patterns of haptoglobin isolated from skin scales and plasma of psoriatic patients.PloS one · 2012Article
- Glycosylation and over-expression of endometriosis-associated peritoneal haptoglobin.Glycoconjugate journal · 2002Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alterations in haptoglobin (Hp) glycosylation were examined in the plasma of the first patient with carbohydrate-deficient glycoprotein syndrome (CDGS) who was described in Poland. Hp concentration in the CDGS patient plasma was low (240 mg/l) and the Hp phenotype was shown to be 2-2. Three glycoforms of the Hp beta subunit were observed in SDS-PAGE in CDGS. The densitometric analysis and molecular weight determinations suggested that 50% of glycoforms were fully glycosylated; 30% contained three out of four and 20% only two out of four glycan units compared to those that are present in Hp derived from healthy people. Results with lectins (concanavalin A and Sambucus nigra, Maackia amurensis and Alleuria aurantia agglutinins) indicate that all three glycoforms of beta subunit of CDGS-Hp contained biantennary complex glycans terminated with alpha2,6 bound sialic acid, but without fucose or alpha2,3 linked sialic acid. Hp glycosylation abnormalities described in this work suggest that this case was a type I carbohydrate-deficient glycoprotein syndrome.
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