ArticleThe EMBO journal2000
Acetylation of GATA-3 affects T-cell survival and homing to secondary lymphoid organs.
Article in The EMBO journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 119 citations in OpenAlex.
- Metabolic Reprogramming and ILC2 Plasticity in Obesity-related Asthma.Clinical reviews in allergy & immunology · 2026Review
- Transcriptional network dynamics in early T cell development.The Journal of experimental medicine · 2024Review
- In-depth organic mass cytometry reveals differential contents of 3-hydroxybutanoic acid at the single-cell level.Nature communications · 2024Article
- GATA-3 is a proto-oncogene in T-cell lymphoproliferative neoplasms.Blood cancer journal · 2022Article
- Stage-specific action of Runx1 and GATA3 controls silencing of PU.1 expression in mouse pro-T cells.The Journal of experimental medicine · 2021Article
- Post-Translational Modifications in Transcription Factors that Determine T Helper Cell Differentiation.Molecules and cells · 2021Review
- How transcription factors drive choice of the T cell fate.Nature reviews. Immunology · 2021Review
- Histone deacetylase function in CD4Nature reviews. Immunology · 2018Review
- HDAC4 is expressed on multiple T cell lineages but dispensable for their development and function.Oncotarget · 2017Article
- HDAC Inhibitors as Epigenetic Regulators of the Immune System: Impacts on Cancer Therapy and Inflammatory Diseases.BioMed research international · 2016Review
- Eukaryotic enhancers: common features, regulation, and participation in diseases.Cellular and molecular life sciences : CMLS · 2015Review
- Histone acetyltransferases and histone deacetylases in B- and T-cell development, physiology and malignancy.Genes & cancer · 2015Review
- Unconventional post-translational modifications in immunological signaling.Nature immunology · 2014Review
- GATA3: a master of many trades in immune regulation.Trends in immunology · 2014Review
- Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Molecular cloning of grass carp (Ctenopharyngodon idellus) T-bet and GATA-3, and their expression profiles with IFN-γ in response to grass carp reovirus (GCRV) infection.Fish physiology and biochemistry · 2013Article
- Histone deacetylase inhibitors (HDACIs): multitargeted anticancer agents.Biologics : targets & therapy · 2013Article
- Article
- A novel immunodeficiency disorder characterized by genetic amplification of interleukin 25.Genes and immunity · 2011Article
- Structural basis and specificity of acetylated transcription factor GATA1 recognition by BET family bromodomain protein Brd3.Molecular and cellular biology · 2011Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acetylation of a transcription factor has recently been shown to play a significant role in gene regulation. Here we show that GATA-3 is acetylated in T cells and that a mutation introduced into amino acids 305-307 (KRR-GATA3) creates local hypoacetylation in GATA-3. Remarkably, KRR-GATA3 possesses the most potent suppressive effect when compared with other mutants that are disrupted in putative acetylation targets. Expressing this mutant in peripheral T cells results in defective T-cell homing to systemic lymphnodes, and prolonged T-cell survival after activation. These findings have significant implications in that the acetylation state of GATA-3 affects its physiological function in the immune system and, more importantly, provides evidence for the novel role of GATA-3 in T-cell survival and homing to secondary lymphoid organs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.