ArticleThe EMBO journal2000
CtrA mediates a DNA replication checkpoint that prevents cell division in Caulobacter crescentus.
Article in The EMBO journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 75 citations in OpenAlex.
- Type IV pilin regulation: a transcriptional overview.Critical reviews in microbiology · 2026Review
- Stress changes the material state of a bacterial biomolecular condensate and shifts its function from mRNA decay to storage.Nature communications · 2025Article
- Upstream CtrA-binding sites both induce and repress pilin gene expression in Caulobacter crescentus.BMC genomics · 2024Article
- Bacteria-on-a-bead: probing the hydrodynamic interplay of dynamic cell appendages during cell separation.Communications biology · 2022Article
- ATP hydrolysis tunes specificity of a AAA+ protease.Cell reports · 2022Article
- DnaJ and ClpX Are Required for HitRS and HssRS Two-Component System Signaling in Bacillus anthracis.Infection and immunity · 2022Article
- Modeling the temporal dynamics of master regulators and CtrA proteolysis in Caulobacter crescentus cell cycle.PLoS computational biology · 2022Article
- Activation of a signaling pathway by the physical translocation of a chromosome.Developmental cell · 2021Article
- LexA Binds to Transcription Regulatory Site of Cell Division Gene ftsZ in Toxic Cyanobacterium Microcystis aeruginosa.Marine biotechnology (New York, N.Y.) · 2018Article
- MtrA Response Regulator Controls Cell Division and Cell Wall Metabolism and Affects Susceptibility of Mycobacteria to the First Line Antituberculosis Drugs.Frontiers in microbiology · 2018Article
- The Essential Role of ClpXP inFrontiers in molecular biosciences · 2017Article
- Cell Cycle Control by the Master Regulator CtrA in Sinorhizobium meliloti.PLoS genetics · 2015Article
- Transcriptome analysis of cyst formation in Rhodospirillum centenum reveals large global changes in expression during cyst development.BMC genomics · 2015Article
- A DNA damage-induced, SOS-independent checkpoint regulates cell division in Caulobacter crescentus.PLoS biology · 2014Article
- Host plant peptides elicit a transcriptional response to control the Sinorhizobium meliloti cell cycle during symbiosis.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Themes and Variations: Regulation of RpoN-Dependent Flagellar Genes across Diverse Bacterial Species.Scientifica · 2014Review
- Small proteins can no longer be ignored.Annual review of biochemistry · 2014Review
- Computational and genetic reduction of a cell cycle to its simplest, primordial components.PLoS biology · 2013Article
- The DivJ, CbrA and PleC system controls DivK phosphorylation and symbiosis in Sinorhizobium meliloti.Molecular microbiology · 2013Article
- Chromosome replication and segregation govern the biogenesis and inheritance of inorganic polyphosphate granules.Molecular biology of the cell · 2013Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Coordination of DNA replication and cell division is essential in order to ensure that progeny cells inherit a full copy of the genome. Caulobacter crescentus divides asymmetrically to produce a non-replicating swarmer cell and a replicating stalked cell. The global response regulator CtrA coordinates DNA replication and cell division by repressing replication initiation and transcription of the early cell division gene ftsZ in swarmer cells. We show that CtrA also mediates a DNA replication checkpoint of cell division by regulating the late cell division genes ftsQ and ftsA. CtrA activates transcription of the P(QA) promoter that co-transcribes ftsQA, thus regulating the ordered expression of early and late cell division proteins. Cells inhibited for DNA replication are unable to complete cell division. We show that CtrA is not synthesized in pre-divisional cells in which replication has been inhibited, preventing the transcription of P(QA) and cell division. Replication inhibition prevents the activation of the ctrA P2 promoter, which normally depends on CtrA phosphorylation. This suggests the possibility that CtrA phosphorylation may be affected by replication inhibition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.