ArticleThe EMBO journal2000
Genome-wide variation of the somatic mutation frequency in transgenic plants.
Article in The EMBO journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 152 citations in OpenAlex.
- Transgenerational somatic mutations and epigenetic imprints on selected DNA repair gene promoters in Arabidopsis thaliana due to pesticides.Plant biology (Stuttgart, Germany) · 2026Article
- The population structure of invasiveeLife · 2026Article
- Persistence of parental age effect on somatic mutation rates across generations in Arabidopsis.BMC plant biology · 2023Article
- Somatic Mutations in Fruit Trees: Causes, Detection Methods, and Molecular Mechanisms.Plants (Basel, Switzerland) · 2023Review
- The applicability of the European GMO legislation to epigenetically modified organisms.Frontiers in bioengineering and biotechnology · 2023Article
- Genetic resources and breeding of maize forFrontiers in plant science · 2023Review
- Development of a simple multiple mutation detection system using seed-coat flavonoid pigments in irradiated Arabidopsis MScientific reports · 2022Article
- Analysis of the Whole-Genome Sequences from anGenes · 2022Article
- Natural and artificial sources of genetic variation used in crop breeding: A baseline comparator for genome editing.Frontiers in genome editing · 2022Review
- Canadian Consumer Preferences Regarding Gene-Edited Food Products.Frontiers in genome editing · 2022Article
- Discovery and Characterization of a Novel TomatoGenes · 2021Article
- The Genome-Wide EMS Mutagenesis Bias Correlates With Sequence Context and Chromatin Structure in Rice.Frontiers in plant science · 2021Article
- NGS sequencing reveals that many of the genetic variations in transgenic rice plants match the variations found in natural rice population.Genes & genomics · 2019Article
- Translesion Synthesis in Plants: Ultraviolet Resistance and Beyond.Frontiers in plant science · 2019Review
- Effect of Hybridization on Somatic Mutations and Genomic Rearrangements in Plants.International journal of molecular sciences · 2018Review
- Deletion of TLS polymerases promotes homologous recombination in Arabidopsis.Plant signaling & behavior · 2018Article
- Brief temperature stress during reproductive stages alters meiotic recombination and somatic mutation rates in the progeny of Arabidopsis.BMC plant biology · 2017Article
- Non-coding RNAs match the deleted genomic regions in humans.Scientific reports · 2016Article
- Suppression of different classes of somatic mutations in Arabidopsis by vir gene-expressing Agrobacterium strains.BMC plant biology · 2015Article
- Parental age affects somatic mutation rates in the progeny of flowering plants.Plant physiology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In order to analyse the frequency of point mutations in whole plants, several constructs containing single nonsense mutations in the beta-glucuronidase (uidA) gene were used to generate transgenic Arabidopsis thaliana plants. Upon histochemical staining of transgenic plants, sectors indicative of transgene reactivation appeared. Reversion frequencies were in the range of 10(-7)-10(-8) events per base pair, exceeding the previous estimates for other eukaryotes at least 100-fold. The frequency was dependent on the position of the mutation substrate within the transgene and the position of the transgene within the Arabidopsis genome. An inverse relationship between the level of transgene transcription and mutation frequency was observed in single-copy lines. DNA-damaging factors induced the mutation frequency by a factor of up to 56 for UV-C, a factor of 3 for X-rays and a factor of 2 for methyl methanesulfonate. This novel plant mutation-monitoring system allowed us to measure the frequencies of point mutation in whole plants and may be used as an alternative or complement to study the mutagenicity of different environmental factors on the higher eukaryote's genome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.