ArticleThe Biochemical journal2000
Coupling between inositol 1,4,5-trisphosphate receptors and human transient receptor potential channel 1 when intracellular Ca2+ stores are depleted.
Article in The Biochemical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 163 citations in OpenAlex.
- The discovery and development of IP3 receptor modulators: an update.Expert opinion on drug discovery · 2021Article
- Naringenin Inhibits Platelet Activation and Arterial Thrombosis Through Inhibition of Phosphoinositide 3-Kinase and Cyclic Nucleotide Signaling.Frontiers in pharmacology · 2021Article
- The functions of store-operated calcium channels.Biochimica et biophysica acta. Molecular cell research · 2017Review
- Antiplatelet and antithrombotic effects of cordycepin-enriched WIB-801CE from Cordyceps militaris ex vivo, in vivo, and in vitro.BMC complementary and alternative medicine · 2016Article
- STIM and Orai1 Variants in Store-Operated Calcium Entry.Frontiers in pharmacology · 2015Review
- Inhibitory Effects of Cytosolic Ca(2+) Concentration by Ginsenoside Ro Are Dependent on Phosphorylation of IP3RI and Dephosphorylation of ERK in Human Platelets.Evidence-based complementary and alternative medicine : eCAM · 2015Article
- Interactions of antagonists with subtypes of inositol 1,4,5-trisphosphate (IP3) receptor.British journal of pharmacology · 2014Article
- Cytoskeleton reorganization as an alternative mechanism of store-operated calcium entry control in neuroendocrine-differentiated cells.PloS one · 2012Article
- Type 2 inositol 1,4,5-trisphosphate receptor modulates bile salt export pump activity in rat hepatocytes.Hepatology (Baltimore, Md.) · 2011Article
- The physiological function of store-operated calcium entry.Neurochemical research · 2011Review
- TRPC3 regulates agonist-stimulated Ca2+ mobilization by mediating the interaction between type I inositol 1,4,5-trisphosphate receptor, RACK1, and Orai1.The Journal of biological chemistry · 2010Article
- TRPC channels function independently of STIM1 and Orai1.The Journal of physiology · 2009Article
- Granulosa cells express three inositol 1,4,5-trisphosphate receptor isoforms: cytoplasmic and nuclear Ca2+ mobilization.Reproductive biology and endocrinology : RB&E · 2008Article
- Store-operated Ca(2+) entry in platelets occurs independently of transient receptor potential (TRP) C1.Pflugers Archiv : European journal of physiology · 2008Article
- Protein complex immunological separation assay (ProCISA): a technique for investigating single protein properties.Journal of physiology and biochemistry · 2008Article
- Orai, STIM1 and iPLA2beta: a view from a different perspective.The Journal of physiology · 2008Article
- TRP channels in hypertension.Biochimica et biophysica acta · 2007Review
- Lipid rafts establish calcium waves in hepatocytes.Gastroenterology · 2007Article
- Inositol trisphosphate receptor Ca2+ release channels.Physiological reviews · 2007Review
- A role for 5,6-epoxyeicosatrienoic acid in calcium entry by de novo conformational coupling in human platelets.The Journal of physiology · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study we have investigated the role of inositol 1,4, 5-trisphosphate (IP(3)), functional IP(3) receptors (IP(3)Rs) and the human homologue of the Drosophila transient receptor potential (Trp) channel, human Trp1 (hTrp1), in store-mediated Ca(2+) entry (SMCE) in human platelets. Inhibition of IP(3) recycling using Li(+), or the inhibition of IP(3)Rs using xestospongin C, both resulted in the inhibition of SMCE activation following Ca(2+) store depletion using thapsigargin. Co-immunoprecipitation experiments indicated that endogenously expressed hTrp1 couples with IP(3)R type II, but not types I or III, in platelets with depleted intracellular Ca(2+) stores, but not in control, undepleted cells. These results provide strong evidence for the activation of SMCE by conformational coupling involving de novo association between IP(3)Rs and a plasma membrane channel in normal human cells.
Indexed as
Identifiers
10970773PMC1221291W2027094257What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.