ReviewEnvironmental health perspectives1999
Evidence for the role of environmental agents in the initiation or progression of autoimmune conditions.
Review in Environmental health perspectives, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis.Molecular biology reports · 2013Pooled it
- Nested case-control study of autoimmune disease in an asbestos-exposed population.Environmental health perspectives · 2006Trial
- Polybrominated biphenyls (PBBs) and prevalence of autoimmune disorders among members of the Michigan PBB registry.Environmental research · 2023Article
- The increasing prevalence of autoimmunity and autoimmune diseases: an urgent call to action for improved understanding, diagnosis, treatment, and prevention.Current opinion in immunology · 2023Review
- A toxicological profile of silica nanoparticles.Toxicology research · 2022Review
- The EXIMIOUS project-Mapping exposure-induced immune effects: connecting the exposome and the immunome.Environmental epidemiology (Philadelphia, Pa.) · 2022Article
- Autoimmune conditions in the World Trade Center general responder cohort: A nested case-control and standardized incidence ratio analysis.American journal of industrial medicine · 2022Article
- Review of Non-Respiratory, Non-Cancer Physical Health Conditions from Exposure to the World Trade Center Disaster.International journal of environmental research and public health · 2018Review
- Multiple sclerosis and environmental risk factors: a case-control study in Iran.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2017Article
- Occupational exposures at a polyvinyl chloride production facility are associated with significant changes to the plasma metabolome.Toxicology and applied pharmacology · 2016Article
- Considerations Before Establishing an Environmental Health Registry.American journal of public health · 2015Article
- Nested case-control study of selected systemic autoimmune diseases in World Trade Center rescue/recovery workers.Arthritis & rheumatology (Hoboken, N.J.) · 2015Article
- Primary biliary cirrhosis: Family, genes, and bugs.Clinical liver disease · 2014Review
- X-ray radiation and the risk of multiple sclerosis: Do the site and dose of exposure matter?Medical journal of the Islamic Republic of Iran · 2014Article
- Article
- Environmental toxin 4-nonylphenol and autoimmune diseases: using DNA microarray to examine genetic markers of cytokine expression.Archives of medical science : AMS · 2010Article
- Global DNA hypomethylation is associated with high serum-persistent organic pollutants in Greenlandic Inuit.Environmental health perspectives · 2008Article
- Antimitochondrial antibodies in acute liver failure: implications for primary biliary cirrhosis.Hepatology (Baltimore, Md.) · 2007Article
- The importance of gene-environment interactions and exposure assessment in understanding human diseases.Journal of exposure science & environmental epidemiology · 2006Article
- Assessment of autoimmune responses associated with asbestos exposure in Libby, Montana, USA.Environmental health perspectives · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The concordance of autoimmune disease among identical twins is virtually always less than 50% and often in the 25-40% range. This observation, as well as epidemic clustering of some autoimmune diseases following xenobiotic exposure, reinforces the thesis that autoimmune disease is secondary to both genetic and environmental factors. Because nonliving agents do not have genomes, disease characteristics involving nonliving xenobiotics are primarily secondary to host phenotype and function. In addition, because of individual genetic susceptibilities based not only on major histocompatibility complex differences but also on differences in toxin metabolism, lifestyles, and exposure rates, individuals will react differently to the same chemicals. With these comments in mind it is important to note that there have been associations of a number of xenobiotics with human autoimmune disease, including mercury, iodine, vinyl chloride, canavanine, organic solvents, silica, l-tryptophan, particulates, ultraviolet radiation, and ozone. In addition, there is discussion in the literature that raises the possibility that xenobiotics may also exacerbate an existing autoimmune disease. In this article we discuss these issues and, in particular, the evidence for the role of environmental agents in the initiation or progression of autoimmune conditions. With the worldwide deterioration of the environment, this is a particularly important subject for human health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.